类弹性蛋白-蚕丝纤维复合材料的制备及性能研究

功能材料, 2017, 48(6): 6097-6108. doi: 10.3969/j.issn.1001-9731.2017.06.017

类弹性蛋白-蚕丝纤维复合材料的制备及性能研究

陈卓玥 ^1, , 魏琪 ^2, , 王晋荣 ^3, , 龙开平 ^4, , 李红民 ^5,

1.西京学院护理系,西安 710123;西北大学生命科学学院,西安 710069

2.西北大学生命科学学院,西安,710069

3.西京学院护理系,西安,710123

4.西京学院护理系,西安,710123

5.西北大学生命科学学院,西安,710069

基金项目: 西京学院科研基金资助项目(XJ150130) 陕西省教育厅专项科研计划资助项目(16JK2245)

关键词：类弹性蛋白 , 蚕丝纤维 , 多孔支架 , 性能 , 细胞相容性

Fabrication and property study of elastin-like polypeptide and silk complex scaffold

Keywords： elastin-like polypeptide , silk fiber , porous scaffold , property , cytocompatibility

采用热交联、京尼平交联、原花青素交联和戊二醛/聚乙二醇交联4种方法制备类弹性蛋白-蚕丝纤维多孔支架材料.利用扫描电镜、傅立叶变换红外光谱和力学性能测试研究了交联类弹性蛋白-蚕丝纤维多孔材料的内部形态和结构.通过细胞毒性实验分析了不同方法交联类弹性蛋白-蚕丝纤维多孔材料的细胞相容性.结果表明,热交联和京尼平交联能制备出的类弹性蛋白-蚕丝纤维多孔支架材料具有较高和较稳定的力学性能,且具有良好的细胞相容性.

Silk microfibers and Elastin-like polypeptide (ELP) were treated with four methods, (1) Dehydrothermal treatment (DHT);(2) mixing with genipin;(3) mixing with proanthocyanidin (PA);(4) mixing with PEG and glutaraldehyde (GA).The resulting materials were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and mechanical properties.The fiber reinforcement (Silk-ELP-DHT, Silk-ELP-Genipin and Silk-ELP-PEG-GA) resulted in the development of more mechanically robust constructs compared to silk alone.Meanwhile, the Silk-ELP-DHT and Silk-ELP-Genipin composite scaffolds show higher and more stable mechanical properties and better cytocompatibility.

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