抗癌新药JM216的晶体结构分析

贵金属, 2001, 22(1): 42-46. doi: 10.3969/j.issn.1004-0676.2001.01.010

抗癌新药JM216的晶体结构分析

陈亮维 ^1, , 普绍平 ^2, , 王耀东 ^3, , 徐滢 ^4,

1.昆明贵金属研究所,

2.昆明贵金属研究所,

3.昆明贵金属研究所,

4.昆明贵金属研究所,

基金项目: 云南省应用基础研究项目(97A045Q)

关键词：顺式-二氯-反式-二乙酸-顺式-氨,环己胺合铂(IV) , 晶体结构

The Crystal Structure Analysis of Anticancer Drug JM216

用X射线衍射方法分析了顺式-二氯-反式-二乙酸-顺式-氨，环己胺合铂(IV)〔PtCl2(C2H3O2)2(C6H13N)(NH3〕的晶体结构，得出了该晶体的粉末衍射数据，结果表明：它属于单斜晶系，晶胞参数a=1.360 1(8)nm，b=0.829 2(2)nm，c=1.468 2(6)nm，β=110.483(35)°。

The crystal structure of anticancer drug bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)PtCl2(C2H3O2)2(C6H13N)(NH3)(JM216)was analyzed by using X-ray diffraction method.The powder diffraction data were obtained.The results show that the structure of the crystal belongs to the monoclinic,with lattice parameters:a=1.360 1(8)nm,b=0.829 2(2)nm，c=1.468 2(6)nm，β=110.483(35)°。

参考文献

[1]	S. Neidle;C. F. Snook;B. A. Murrer;C. F. J. Barnard .Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an Orally Active Anticancer Drug[J].Acta Crystallographica. Sect.C, Section C. Crystal Structure Communications,1995(5):822-824.
[2]	理学电机(Rigaku.X射线衍射手册[M].理学电机株式会社,1987
[3]	Rigaku.[J].Instruction Manual for D/max System Application Software Rigaku Corporation,1987

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