磁性纳米颗粒目前是生物医用纳米材料领域异常活跃的方向之一.不同方法制备的磁性纳米颗粒经不同聚合物或分子表面改性后具有多方面的生物医学应用.本文综合评述了磁性纳米颗粒的制备方法,如共沉淀法、溶胶-凝胶法、微乳剂法等;总结了磁性纳米颗粒表面改性技术,包括改性物质与改性方法;概括了磁性纳米颗粒在生物医学领域的应用,主要涉及磁靶向制剂、细胞分离、肿瘤细胞的过热治疗、MRI衬度增强剂四方面.磁性纳米颗粒还有很大的发展空间和广阔的应用前景.
参考文献
| [1] | Berry CC .Possible exploitation of magnetic nanoparticle-cell interaction for biomedical applications[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2005(5):543-547. |
| [2] | Kim DK.;Voit W.;Rao KV.;Muhammed M.;Zhang Y. .Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles[J].Journal of Magnetism and Magnetic Materials,2001(1/2):30-36. |
| [3] | HILGEB I;FRUK;ANDPA W et al.Heating potential of iron oxides for therapeutic purposes in interventional radiology[J].Academic Radiology,2002,6:198-202. |
| [4] | I. Hilger;R. Hergt;W.A. Kaiser .Use of magnetic nanoparticle heating in the treatment of breast cancer[J].IEE proceedings.Part M.Nanobiotechnology,2005(1):33-39. |
| [5] | Jordan A.;Maier-Hauff K.;Johannsen M.;Wust P.;Nadobny J. Schirra H.;Schmidt H.;Deger S.;Loening S.;Lanksch W.;Felix R.;Scholz R. .Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia[J].Journal of Magnetism and Magnetic Materials,2001(1/2):118-126. |
| [6] | Gupta AK;Gupta M .Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications[J].Biomaterials,2005(18):3995-4021. |
| [7] | CHATTERJEE J;HAIK Y;CHEN C .Size dependent magnetic properties of iron oxide nanopartieles[J].Journal of Magnetism and Magnetic Materials,2003,257:113-118. |
| [8] | TARTAJ P;MORALES M;VINTEMILLAS S et al.The preparation of magnetic nanopartieles for applieations in biomedicine[J].Journal of Physics D:Applied Physics,2003,36:R182-R197. |
| [9] | Raj K.;Casciari R.;Moskowitz B. .ADVANCES IN FERROFLUID TECHNOLOGY[J].Journal of Magnetism and Magnetic Materials,1995(1/2):174-180. |
| [10] | Popplewell J.;Sakhnini L. .THE DEPENDENCE OF THE PHYSICAL AND MAGNETIC PROPERTIES OF MAGNETIC FLUIDS ON PARTICLE SIZE[J].Journal of Magnetism and Magnetic Materials,1995(1/2):72-78. |
| [11] | White R.L.;Newt R.M.H. .Patterned media: a viable route to 50 Gbit/in/sup 2/ and up for magnetic recording?[J].IEEE Transactions on Magnetics,1997(1):990-995. |
| [12] | Pankhurst QA.;Connolly J.;Jones SK.;Dobson J. .Applications of magnetic nanoparticles in biomedicine [Review][J].Journal of Physics, D. Applied Physics: A Europhysics Journal,2003(13):R167-R181. |
| [13] | BERRY C C;CURTIS A G .Functionalisafian of magnetic nanopartieles for applications in biomedicine[J].Journal of Physics D:Applied Physics,2003,36:R198-R206. |
| [14] | KODAS T T;HAMPDEN S M.Aerosol processing of materials[M].New York:Wiley-VCH,1999 |
| [15] | C. S. Lee;H. Lee;R. M. Westervelt .Microelectromagnets for the control of magnetic nanoparticles[J].Applied physics letters,2001(20):3308-3310. |
| [16] | CHATTERJEE J;HAIK Y;CHEN C J .A biocompatible magnetic film:synthesis and characterization[J].Biomagnetic Research and Technology,2004,2(02):1-3. |
| [17] | Berry CC;Wells S;Charles S;Curtis AS .Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro.[J].Biomaterials,2003(25):4551-4557. |
| [18] | Jhunu Chatterjee;Yousef Haik;Ching Jen Chen .Biodegradable magnetic gel:synthesis and characterization[J].Colloid and polymer science,2003(9):892-896. |
| [19] | QU S C;YANG H B;liEN D W et al.Magnetic nanoparticles prepared by precipitation from partially reduced ferric chloride aqueous solutions[J].Journal of Colloid and Interface Science,1999,215:190-192. |
| [20] | KIM D;VOlT W;ZAPKA W et al.Biomedical application of ferrofluids containing magnetite nanoparticles[J].Mat Res Sci Syrup Proc,2001,676:1-6. |
| [21] | PREDOI D;KUNCSER V;FILOTI G et al.Magnetic properties of γ-Fe2O3 nsnoparticles[J].Journal of Optoelectronics and Advanced Materials,2003,5:211-216. |
| [22] | DORMAN J;FIORANI D;TRONC E .Magnetic relaxation in fine-particle systems[J].Advances in Chemical Physics,1997,98:283-286. |
| [23] | Magnetic properties of Fe-doped organic-inorganic nanohybrids[J].Journal of Applied Physics,2003(10):6978-6980. |
| [24] | KORNAK R;NIZNANSKY D;HAIMANN K et al.Synthesis of magnetic nanoparticles via the sol-gel technique[J].MATERIALS SCIENCE-POLAND,2005,23(01):87-92. |
| [25] | GUPTA AK;WELLS S .Surface -modified superparamagnetic nanoparticles for drug delivery:preparation,characterization,and cytotoxicity studies[J].IEEE Transactions on NanoBioscience,2004,3(01):66-73. |
| [26] | Igartua M;Saulnier P;Heurtault B;Pech B;Proust JE;Pedraz JL;Benoit JP .Development and characterization of solid lipid nanoparticles loaded with magnetite.[J].International Journal of Pharmaceutics,2002(1/2):149-157. |
| [27] | Feltin N.;Pileni MP. .NEW TECHNIQUE FOR SYNTHESIZING IRON FERRITE MAGNETIC NANOSIZED PARTICLES[J].Langmuir: The ACS Journal of Surfaces and Colloids,1997(15):3927-3933. |
| [28] | BOUTONNET M;KIZLING J;STENIUS P .The preparation of monodisperse colloidal metal particles from microemulsions[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,1982,5:209-213. |
| [29] | SOHN B;COHEN R;PAPACEFTHYMIOU G .Magnetic properties of iron oxide nsnoparticles within microdomains of block copolymers[J].Journal of Magnetism and Magnetic Materials,1998,182:216-224. |
| [30] | AHMED S;KOFINAS P .Controlled room temperature synthesis of CoFe2O4 nanopartilcles through a block copolymer nanoreactor route[J].Macromolecules,2002,35:3338-3341. |
| [31] | AHMED S;OGALE S;KOFINAS P .Magnetic properties and morphology of block copolymer templated ferromagnetic CoFe2O4 nanoparticles[J].IEEE Transactions on Magnetics,2003,39:2198-2200. |
| [32] | Viau G.;Fievet F.;Fievetvincent F. .NUCLEATION AND GROWTH OF BIMETALLIC CONI AND FENI MONODISPERSE PARTICLES PREPARED IN POLYOLS[J].Solid state ionics,1996(3/4):259-270. |
| [33] | Lin H.;Watanabe Y.;Kimura M.;Hanabusa K.;Shirai H. .Preparation of magnetic poly(vinyl alcohol) (PVA) materials by in situ synthesis of magnetite in a PVA matrix[J].Journal of Applied Polymer Science,2003(8):1239-1247. |
| [34] | ROCKENBERGER J;SCHER E C;ALIVISATOS A P .A New Nonhydrolytic Single-Precursor Approach to Surfactant-Capped Nanocrystals of Transition Metal Oxides[J].Journal of the American Chemical Society,1999,121:11595-11596. |
| [35] | HYEON T;LEE S S;PARK J .Synthesis of Highly Crystalline and Monodisperse Maghemite Nanocrystallites without a Size-Selection Process[J].Journal of the American Chemical Society,2001,123:12798-12801. |
| [36] | Kevin L. Klug;Vinayak P. Dravid;D. Lynn Johnson .Silica-encapsulated magnetic nanoparticles formed by a combined arc evaporation/chemical vapor deposition technique[J].Journal of Materials Research,2003(4):988-993. |
| [37] | VIRENDRA M .Self Controlled Magnetic Hyperthermia[D].Florida:University of Florida,2004. |
| [38] | Chatterjee J;Bettge M;Haik Y;Chen CJ .Synthesis and characterization of polymer encapsulated Cu-Ni magnetic nanoparticles for hyperthermia applications[J].Journal of Magnetism and Magnetic Materials,2005(1):303-309. |
| [39] | BETrGE M;CHATTERJEE J;HAIK Y .Physically synthesized Ni-Cu nanopartieles for rnsgnetie Hyperthermia[J].Biomagnetic Research and Technology,2004,2(04):1-6. |
| [40] | BIDDLECOMBE G;GUNKO Y;KELLY J et al.Preparation of magnetieles and their assemblies using a new Fe(Ⅱ) alkoxide precursor[J].Journal of Materials Chemistry,2001,11:2937-2939. |
| [41] | CHATYERJEE J;HAIK Y;CHEN C J .Polyethylene magnetic annoparticles:a new magnetic material for biomedical applications[J].Journal of Magnetism and Magnetic Materials,2002,246:382-391. |
| [42] | VUAYAKUMAR R;KOLTYPIN Y;FELNER I .Sonochemical synthesis and characterization of pure nanometer-sized Fe3O4 particles[J].Materials Science and Engineering A:Structural Materials Properties Microstructure and Processing,2000,286:101-105. |
| [43] | SHI DONGLU;HE PENG .Surface modifications of nanoparticles and nanotubes by plasma polymerization[J].Reviews on Advanced Materials Science,2004,7:97-107. |
| [44] | KIM D;ZHANG Y;KEHR J et al.Characterization and MRI study of surfactant-coater superparamagnetic nunopartieles administered into the rat brain[J].Journal of Magnetism and Magnetic Materials,2001,225:256-261. |
| [45] | Zhang Y;Kohler N;Zhang M .Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.[J].Biomaterials,2002(7):1553-1561. |
| [46] | Gupta AK;Gupta M .Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles.[J].Biomaterials,2005(13):1565-1573. |
| [47] | HORAKD;LEDNICK F;PETROVSKY E et al.Magnetic characteristics of ferromagnetic mierospheres prepared by dispersion polymerization[J].Macromolecular Materials and Engineering,2004,289:341-348. |
| [48] | Horak D.;Subrt M.;Bohacek J. .Magnetic poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) microspheres by dispersion polymerization[J].Journal of Polymer Science, Part A. Polymer Chemistry,2000(7):1161-1171. |
| [49] | Z.Z. Xu;C.C. Wang;W.L. Yang .Encapsulation of nanosized magnetic iron oxide by polyacrylamide via inverse miniemulsion polymerization[J].Journal of Magnetism and Magnetic Materials,2004(1/2):136-143. |
| [50] | S.A.Gomez-Lopera;R.C.Plaza;A.V.Delgado .Synthesis and Characterization of Spherical Magnetite/Biodegradable Polymer Composite Particles[J].Journal of Colloid and Interface Science,2001(1):40-47. |
| [51] | ZIMMERMANN U;VIENKEN J;PILWAT G .Development of drug carrier systems:Electrical field induced effects in cell membranes[J].Bieclectrochem Bioenerg,1980,7(03):553-574. |
| [52] | Kong,G;Braun,RD;Dewhirst,MW .Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.[J].Cancer research,2000(16):4440-4445. |
| [53] | Alexiou C;Arnold W;Klein R .Loctoregional Cancer Treatment with Magnetic Drug Targeting[J].Cancer Research,2000,60:6641-6648. |
| [54] | FRIEDL P;NOBLE PB;ZANKER KS .Tlymphecyte locomotion in a three-dimensional collagen matrix.Expression and function of cell adhesion molecules[J].Journal of Immunology,1995,154:4973-4977. |
| [55] | HILGER I;KIEβLING A;ROMANUS E et al.Magnetic nanoparticles for selective heating of magnetically labeled cells in culture:preliminary investigation[J].NANOTECHNOLOGY,2004,15:1027-1032. |
| [56] | Gupta AK;Curtis AS .Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors.[J].Biomaterials,2004(15):3029-3040. |
| [57] | Moroz P;Jones SK;Gray BN .Magnetically mediated hyperthermia: current status and future directions.[J].International journal of hyperthermia,2002(4):267-284. |
| [58] | Kawashita M;Tanaka M;Kokubo T;Inoue Y;Yao T;Hamada S;Shinjo T .Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer.[J].Biomaterials,2005(15):2231-2238. |
| [59] | ATKINSON W J;BREZOVICH I A;CHAKRABORTY D P .Usable frequencies in hyperthermia with thermal seeds[J].IEEE Transactions on Biomedical Engineering,1984,31:70-75. |
| [60] | MATSUOKA F;SHINKAI M;H HONDA et al.Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma[J].Biomagnetic Research and Technology,2004,2(03):1-6. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%