叙述了电泳芯片的设计和制作 , 并详细阐述了电泳芯片的进样方法 , 电泳操作方法等 . 实验结果表明 , 本系统能对 DNA片段进行很好的分离和检测 , 检测极限已达到 10-19mol.
参考文献
[1] | Harrison D J;FLURI K;MANZ A et al.Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip[J].Science,1993,261:895-897. |
[2] | EFFENHOUSER C S;MANZ A;WIDMER H M .Glass chips for High-Speed Capillary Electrophotesis Separations with Submicrometer Plate Heights[J].Analytical Chemistry,1993,65:2637-2643. |
[3] | Jacobson S C;HERGENROEDER R;KOUTRY L B et al.High-Speed Separations on a Microchip[J].Analytical Chemistry,1994,66:1114-1118. |
[4] | Woolley AT;Hadley D;Landre P;Demello AJ;Mathies RA;Northrup MA .FUNCTIONAL INTEGRATION OF PCR AMPLIFICATION AND CAPILLARY ELECTROPHORESIS IN A MICROFABRICATED DNA ANALYSIS DEVICE[J].Analytical chemistry,1996(23):4081-4086. |
[5] | Liu SR.;Ja WW.;Mathies RA.;Shi YN. .Optimization of high-speed DNA sequencing on microfabricated capillary electrophoresis channels[J].Analytical chemistry,1999(3):566-573. |
[6] | Hjerten S .High-Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption[J].Journal of Chromatography,1985,347:191-198. |
[7] | Carrilho E;Ruizmartinez MC;Berka J;Smirnov I;Goetzinger W;Miller .RAPID DNA SEQUENCING OF MORE THAN 1000 BASES PER RUN BY CAPILLARY ELECTROPHORESIS USING REPLACEABLE LINEAR POLYACRYLAMIDE SOLUTIONS[J].Analytical chemistry,1996(19):3305-3313. |
[8] | 陈继锋;金庆辉;徐元森.DNA电泳芯片快速检测系统的设计和实现[J]. |
[9] | LANDERS J P.Handbook of Capillary Electrophoresis[M].CRC Press,1997:865-871. |
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