欢迎登录材料期刊网

材料期刊网

高级检索

一种对于电泳微芯片的检测信号进行处理的新方法,可以提高其信号的信噪比.这种基于激光诱导荧光(LIF)检测系统的方法,通过对检测信号进行的一系列低通滤波、放大等处理,从而达到提高信噪比、降低检测限的目的.将本方法应用于DNA片段的分离实验中,可以提高信噪比(SNR)至6-8倍,检测限(LOD)降低至10-10mol/L.

参考文献

[1] Woolley AT;Mathies RA .ULTRA-HIGH SPEED DNA SEQUENCING USING CAPILLARY ELECTROPHORESIS CHIPS[J].Analytical chemistry,1995(20):3676-3680.
[2] Schmalzing D.;Koutny L.;Ziaugra L.;Matsudaira P.;Ehrlich D.;Adourian A. .DNA sequencing on microfabricated electrophoretic devices[J].Analytical chemistry,1998(11):2303-2310.
[3] Figeys D.;Pinto D. .Lab-on-a-chip: A revolution in biological and medical sciences.[J].Analytical chemistry,2000(9):330A-335A.
[4] Susanne R. Wallenborg;Christopher G. Bailey .Separation and Detection of Explosives on a Microchip Using Micellar Electrokinetic Chromatography and Indirect Laser-Induced Fluorescence[J].Analytical chemistry,2000(8):1872-1878.
[5] Lu SX;Yeung E S .Side- entry excitation and detection of square capillary array electrophoresis for DNA sequencing[J].Journal of Chromatography,2000,A853:359-369.
[6] Hadd A G;Goard M P;Rank D R et al.Sub- microliter DNA sequencing for capillary array electrophoresis[J].Journal of Chromatography,2000,A894:191-201.
[7] Randy M. McCormick;Robert J. Nelson;M. Goretty Alonso-Amigo .Microchannel Electrophoretic Separations of DNA in Injection-Molded Plastic Substrates[J].Analytical chemistry,1997(14):2626-2630.
[8] Hjerté n S .High- performance electrophoresis elimination of electroendosomosis and solute adsorption[J].Journal of Chromatography,1985,A347:191-198.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%