重离子辐射哺乳动物细胞敏感性的分子机理

原子核物理评论 , 2003, 20(1): 42-47. doi: 10.3969/j.issn.1007-4627.2003.01.008

重离子辐射哺乳动物细胞敏感性的分子机理

李文建 ^1, , 周光明 ^2, , 卫增泉 ^3, , 王菊芳 ^4, , 李强 ^5, , 党秉荣 ^6, , 颉红梅 ^7,

1.中国科学院近代物理研究所,甘肃,兰州,730000

2.中国科学院近代物理研究所,甘肃,兰州,730000

3.中国科学院近代物理研究所,甘肃,兰州,730000

4.中国科学院近代物理研究所,甘肃,兰州,730000

5.中国科学院近代物理研究所,甘肃,兰州,730000

6.中国科学院近代物理研究所,甘肃,兰州,730000

7.中国科学院近代物理研究所,甘肃,兰州,730000

基金项目: 中国科学院"西部之光"人才培养计划(XB980604) 中国科学院院长基金(TB990601)

关键词：重离子 , 哺乳动物细胞 , 辐射敏感性 , 分子机理

A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

研究了用传能线密度125.5 keV/μm的 12C6+ 辐照小鼠黑色素瘤、中国仓鼠肺、人的宫颈癌、人的肝癌细胞的敏感性以及DNA双链断裂和DNA双链断裂片段分布,结果表明细胞敏感性与DNA双链断裂之间没有一致的关系,提出了细胞辐射敏感性的一种可能的分子机理,即DNA序列敏感性位点协同DNA双链断裂互补性机理. 由此解释了4种细胞系的不同敏感性问题.

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重离子辐射哺乳动物细胞敏感性的分子机理

A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

参考文献