辐射介导自杀基因和p53及其靶基因靶向治疗

原子核物理评论 , 2005, 22(3): 284-287. doi: 10.3969/j.issn.1007-4627.2005.03.012

辐射介导自杀基因和p53及其靶基因靶向治疗

1.中国科学院近代物理研究所,甘肃,兰州,730000;中国科学院研究生院,北京,100039

2.中国科学院近代物理研究所,甘肃,兰州,730000

基金项目: 中国科学院"百人计划"(BR030601)

Suicide Genes or p53 Gene and p53 Target Genes as Targets for Cancer Gene Therapy by Ionizing Radiation

由于临床治疗剂量对正常组织造成严重损伤,使得放疗存在一些不足.刚刚兴起的肿瘤基因治疗同样存在一些弊端,如对肿瘤组织缺乏特异性,治疗基因表达水平有限,有潜在的生物危险性等.在一定程度上,辐射靶向诱导自杀基因和p53基因及p53靶基因靶向基因治疗可弥补以上两种疗法的不足.该治疗方法不仅可以弥补单独放疗或单独基因治疗的不足,而且可在降低各自治疗剂量的基础上提高疗效.目前已有几种符合要求的表达载体进入临床试验.着重介绍了离子辐射介导自杀基因或p53基因及p53靶基因的辐射靶向基因治疗的研究进展.

参考文献

[1]	Weichselbaum R R, Hallahan D E, Sukhatme V P, et al. Int J Radiat Oncol Biol Phys, 1992, 24: 565.
[2]	Hallahan D E, Mauceri H J, Seung L P, et al. Nat Med, 1995,1: 786.
[3]	Chung T D, Mauceri H J, Hallahan D E, et al. Cancer Gene Ther, 1998, 5: 344.
[4]	Mauceri H J, Seetharam S, Beckett M A, et al. Int J Cancer,2002, 97: 410.
[5]	Kircheis R, Wagner E T. Curr Opin Mol Ther, 2003, 5: 437.
[6]	Kufe D, Weichselbaum R R. Cancer Biol Ther, 2003, 2: 326.
[7]	Joki T, Nakamura M, Ohno T. Hum Gene Ther, 1995,6:1 507.
[8]	Chrity B A, Lau L F, Nathans D. Proc Natl Acad Sci, USA,1988, 85:7 857.
[9]	Marples B, Scott S D, Hendry J H, et al. Gene Ther, 2000, 7:511.
[10]	Scott S D, Joiner M C, Marples B. Gene Ther, 2002, 9:1 396.
[11]	Scott S D, Marples B, Hendry J H, et al. Gene Ther, 2000, 7:1 121.
[12]	Greco O, Marples B, Dachs G V, et al. Gene Ther, 2002, 9:1 403.
[13]	Salloum R M, Saunders M P, Mauceri HJ, et al. Am Surg,2003, 69: 24.
[14]	Worthington J, Robson T, Murray M, et al. Gene Ther, 2000, 7:1 126.
[15]	Marples B, Greco O, Joiner M C, et al. Curr Pharm Des, 2003,9:2 105.
[16]	Soler M N, Bobe P, Benihoud K, et al. J Gene Med, 2000, 2:344.
[17]	Worthington J, Robson T, O' Keeffe M, et al. Gene Ther, 2002,9: 263.
[18]	Amundon S A, Fornace A J. Radiat Prot Dosim, 2001,97: 11.
[19]	Khodarev N N, Park J O, Yu J, et al. Proc Natl Acad Sci, USA,2001, 98:12 665.
[20]	Amundson S A, Bittner M, Fornace Jr. Oncogene, 2003, 22:5 828.
[21]	Amundson S A, Bittner M, Chen Y, et al. Oncogene, 1999,18:3 666.
[22]	Hanahan D, Weiberg R A. Cell, 2000, 100:57
[23]	Levine A J. Cell, 1997, 88: 323.
[24]	Bakkenist C J, Kastan M B. Nature, 2003, 421: 499.
[25]	Vogelstein B, Lane D, Levine A J. Nature, 2000, 408: 307.
[26]	Wang Y H, Tsay Y G, Tan B C, et al. J Biol Chem, 2003,278:25 568.
[27]	Nikolac A Y, Li M, Puskas N, et al. Cell, 2003, 112: 29.
[28]	Zacchi P, Gostissa M, Uchida T, et al. Nature, 2002, 419: 853.
[29]	Kousodontis G, Tentes I, Papakosta P,et al. J Biol Chem, 2001,76:29 116.
[30]	Russo T, Zambrano N, Esposito F, et al. J Biol Chem, 1995,270: 29 386.
[31]	Akashi M, Hachiya M, Osawa Y, et al. J Biol Chem,1995,270:19 181.
[32]	Bunz F, Dutriaux A, Lengauer C, et al. Science, 1998, 282:1 497.
[33]	Hermeking H, Lengauer C, Polyak K, et al. Mol Cell, 1997, 1:3.
[34]	Zhan Q, Antinore M J, Wang X W, et al. Oncogene, 1999, 18:2 892.
[35]	Amundson S A, Do K T, Fornace Jr A J. Radiat Res,1999, 152:225.

上一张下一张

计量

下载量()
访问量()

作者相关

在本站搜索
刘兵张红
在百度学术搜索
刘兵张红
在万方数据库搜索
刘兵张红
在CNKI搜索
刘兵张红

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网

辐射介导自杀基因和p53及其靶基因靶向治疗

Suicide Genes or p53 Gene and p53 Target Genes as Targets for Cancer Gene Therapy by Ionizing Radiation

参考文献