介绍了在DNA辐射损伤以及相关生物、物理、化学问题的一些研究工作.重点是径迹结构、DNA双链断裂和细胞学终点的关系.P53-Mdm2负反馈回路在DNA损伤的细胞响应方面起重要作用,用一个简单的模型研究了P53-Mdm2负反馈回路相互作用的动力学行为.
Some of recent works are presented on radiation induced DNA damage being carried out at China Institute of Atomic Energy (CIAE) and related bio-chemi-physical problems. Emphasis is placed on track structure and its relatio n to the cell end-point, and a simple model proposed to study the dynamical behavior of P53-Mdm2 interaction which plays pivotal role in cellular response to DNA damage.
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