带电粒子致细胞失活的理论模型

原子核物理评论 , 2007, 24(2): 94-97. doi: 10.3969/j.issn.1007-4627.2007.02.003

带电粒子致细胞失活的理论模型

曹天光 ^1, , 马云志 ^2, , 孔福全 ^3, , 杨明建 ^4, , 卓益忠 ^5,

1.中国原子能科学研究院,北京,102413

2.北京大学医学物理和工程北京市重点实验室,肿瘤物理诊疗中心,北京,100871

3.中国原子能科学研究院,北京,102413

4.中国原子能科学研究院,北京,102413;河北工业大学理学院,天津,300130

5.中国原子能科学研究院,北京,102413

基金项目: 国家自然科学基金(10647146;10435020;10175095)

关键词：存活率 , DNA损伤

Theoretical Models of Cell Inactivation by Ionizing Particles

Keywords： cell survival fraction , DNA damage

介绍了经辐射损伤后细胞失活或存活的理论模型及相关问题的一些研究工作.重点考虑了径迹结构和能量沉积特点的新的细胞失活模型.在径迹结构模拟的基础上,计算并分析了DNA损伤谱,同时把径迹结构得到的损伤谱与细胞存活联系起来,初步在分子水平上理解了细胞失活或存活的机制.

The several theoretical models of cell inactivation or cell survival fraction are introduced.Emphasis is placed on a new model--Ionization Ionization Clustering Cluster model. In order to understand some of the mechanisms of DNA damage related to cell killing and their dependence on radiation quality, the yields of single track lethal events are compared with the estimated yields of different classes of complex DNA lesions calculated by a fast Monte Carlo methods.

参考文献

[1]	Lea D E.Actions of Radiations on Living Cells.London:Cambridge University Press,1946,1-402.
[2]	Natarajan A T,Obe G.Mutat Res,1996,366:65.
[3]	Chadwick K H,Leenhouts H P.The Molecular Theory of Radiation Biology.Berlin:Springer-Verlag,1981,1.
[4]	Sachs R K,Hahnfeld P,Brenner D J.Int J Radiat Biol,1997,72:351.
[5]	Nilsson P,Thames H D,Joiner M C.Int J Radiat Biol,1990,57:127.
[6]	Scholz M,Kraft G.Radiat Prot Dosim,1994,52:29.
[7]	Scholz M,Kellerer A M,Kraft-Weyrather W,et al.Radiat Environ Biophys,1997,36:59.
[8]	Kundrát P,Lokají(c)ek M,Hrom(c)íková H.Phys Med Biol,2005,50:1 433.
[9]	Ma Yunzhi,Zhou Hongyu,Zhuo Yizhong.International Journal of Modern Physics,2005,B19:2 933.
[10]	Bird R P,Rohrig N,Colvett R D,et al.Radiat Res,1980,82:277.
[11]	Kundrát P,Stewart R D.eprint,http://arxiv.org/abs/physics/0512030.

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