采用一套专门设计的由微创光纤探头组成的光纤光谱仪生物组织光学参数测试系统,实时在位地获取C6胶质瘤大鼠脑组织的近红外光学参数,探讨以此为指标判别肿瘤基本信息、辅助临床诊断的可能性.利用该测试系统对患有C6胶质瘤的大鼠脑部肿瘤侧和正常侧进行近红外光谱检测.实验结果表明:优化散射系数和血氧饱和度可反映肿瘤位置及病理分化程度信息.证实近红外微探针技术对胶质瘤定性诊断是可行的,为近红外光谱技术临床应用打下基础.
参考文献
[1] | Li Rong,Qian Zhiyu,Dai Lijuan.Automatic measurement system of NIR spectrum of biological tissue based on virtual instruments[J].Computer Measurement & Control(计算机测量与控制),2007,15(2):154-156(in Chinese). |
[2] | Moorthy R K,Rajshekhar V.Development of glioblastoma multiforme following traumatic cerebral contusion:case report and review of literature[J].Surg.Neurol.,2004,61:180-184. |
[3] | Zhang L,Zhang L S,Xu T,et al.Acta photonica sinica[J].2004,33(11):1377-1381. |
[4] | Qian Zhiyu,Gu Yueqing,Liu Hanli.Invivo and real time measurement of rat brain reduced scattering coefficient(μ's)[J].Chinese Journal of Medical Physics(中国医学物理学杂志),2005,22(2):463-465(in Chinese). |
[5] | Nikolaus P,Christiane P,Markus R,et al.Measurement of absolute values of hemoglobin oxygenation in the brain of small rodents by near infrared reflection electrophotometry[J].Journal of Neuroseience Methods,2002,114:107-117. |
[6] | Gaigneaux A,Decaestecker C,Camby I,et al.The infrared spectrum of human glioma cells is related to their in vitro and in vivo behavior[J].Experimental Cell Research,2004,297(1):294-301. |
[7] | Li Kuanzheng,Yang Tianming,Qian Zhiyu,et al.In vivo measurement of hemoglobin saturation of C6 gliomabearing of rat's brain by near infrared spectrometer(NIRS)[C].Biomedical Photonics Annual Meeting 2006 in Jiangsu Province,2006,25-30. |
[8] | Asgari S,Rohrborn H J,Engelhorn T,et al.Intra-operative characterization of gliomas by near-infrared spectroscopy:possible association with prognosis[J].Acta Neurochir.,2003,145:453-460. |
[9] | Dai Lijuan,Qian Zhiyu,Wang Huinan.An optical coherence tomography systerm using frequency-domain optical delay line[J].Chinese Journal of Quantum Electronics(量子电子学报),2006,23(4):456-460(in Chinese). |
[10] | Dai Lijuan,Qian Zhiyu,Wang Huinan.Noninvasive monitoring adult hemodynamic and oxygenation variables'changes in response to sensory stimulation by near-infrared spectroscopy[C].Proceedings of the International Symposium on Biophotonics,Nanophotonics and Metamaterials,Zhejiang:University Press,IEEE,2006,166-169. |
[11] | Ling Mingsheng,Qian Zhiyu,Liang Chaoying.Research on blood glucose concentration monitoring by fluorescence spectrum[J].Chinese Journal ol Quantum Electronics(量子电子学报),2007,24(5):635-639(in Chinese). |
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