以血液接触环境下的应用为目标,研究了单壁碳纳米管无纺膜的抗凝血性能.通过扫描电镜(SEM)观察和表面元素分析,研究了与凝血过程密切相关的纤维蛋白原、白蛋白以及新鲜血浆在单壁碳纳米管无纺膜表面的吸附行为,并利用SEM和荧光标记流式细胞分析技术(FCM),从血小板活化形态和血小板膜糖蛋白的构型变化两个方面分析了单壁碳纳米管无纺膜对血小板的作用.实验结果显示,单壁碳纳米管无纺膜对血液中的纤维蛋白分子原具有明显的倾向性吸附,但是并没有像已有的大部分生物材料一样引起明显的后续血小板粘附和活化,材料与血浆接触后,表面上没有观察到可辨识的血小板粘附与活化,富血小板血浆(PRP)中活化血小板在5%左右,表明该材料具有独特的抑制血小板粘附、活化和聚集的抗凝血性能.这种优异的抗凝血性能在血液接触环境中的人工器官、组织替代物、以及可植入器件等方面具有巨大的潜在应用价值.
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