用聚乙二醇为原料合成N,N'-二甲基甘氨酸单羟基聚乙二醇酯(APEG),并对每步合成的产物用傅立叶变换红外光谱(FTIR)和1H-NMR表征.聚氨酯表面分别引入多氨基聚合物(聚丙烯酰胺和氨基硅油),再接枝APEG,最后在聚氨酯膜表面进行与丙磺酸内酯的开环反应,实现末端带磺铵两性离子聚乙二醇在聚氨酯表面的固定.采用环境扫描电镜(SEM)观察聚合物膜的表面形貌,用光电子能谱(XPS)分析聚合物膜表面元素含量.结果表明:合成的APEG与预定结构一致,通过此法接枝后聚合物膜表面S原子分数分别达1.9%,0.5%,磺铵两性结构成功构建到聚合物膜表面,并且提高了接枝率.
参考文献
| [1] | Anderson J M;Hiitner A;Wiggins M J et al.Recent advances in biomedical polyurethane biostability and biodegradation[J].Polymer International,1998,46(03):163-171. |
| [2] | Stokes K;McVenes R;Anderson J M .Polyurethane elas-tomer biostability[J].Journal of Biomaterials Applications,1995,9(04):321-354. |
| [3] | Howard G T .Biodegradation of polyurethane:a review[J].International Biodeterioration and Biodegradation,2002,49(04):245-252. |
| [4] | Takahara A;Coury AJ;Hergenrother R W et al.Effect of soft segment chemistry on the biostability of segmented polyurethanes.I.In vitro oxidation[J].Journal of Biomedical Materials Research,1991,25(03):341-346. |
| [5] | Wiggins M J;Wilkoff B;Anderson J M et al.Biodegra-dation of polyether polyurethane inner insulation in bipolar pacemaker leads[J].Journal of Biomedical Materials Research,2001,58(03):302-307. |
| [6] | Zhao Q;Agger M P;Fitzpatrick M et al.Cellular inter-actions with biomaterials:In vivo cracking of pre-stressed pellethane 2363-80A[J].Journal of Biomedical Materials Research,1990,24(05):621-637. |
| [7] | Zhao Q;Topham N;Anderson J M et al.Foreign-body giant cells and polyurethane biostability:In vivo cor-relation of cell adhesion and surface cracking[J].Journal of Biomedical Materials Research,1991,25(02):177-183. |
| [8] | Tanzi MC;Mantovani D;Petrini P et al.Chemical sta-bility of polyether urethanes versus polycarbonate ure-thanes[J].Journal of Biomedical Materials Research,1997,36(04):550-559. |
| [9] | Shan-hui Hsu;Zu-Chang Lin .Biocompatibility and biostability of a series of poly(carbonate)urethanes[J].Colloids and Surfaces, B. Biointerfaces,2004(1):1-12. |
| [10] | Pinchuk L .A review of the biostability and carcinogenic-ity of polyurethanes in medicine and the new generation of ' biostable' polyurethanes[J].Journal of Biomaterials Science:Polymer Edition,1994,6(03):225-267. |
| [11] | Thomas V;Kurnari T V;Jayabalan M .In vitro studies on the effect of physical cross-Linking on the biological performance of aliphatic poly (urethane urea) for blood contact applications[J].Biomacromolecules,2001,2(02):588-596. |
| [12] | Capone C D .Biostability of a non-ether polyurethane[J].Journal of Biomaterials Applications,1992,7(02):108-129. |
| [13] | 林思聪.高分子生物材料分子工程研究进展(上)[J].高分子通报,1997(01):1-7. |
| [14] | Zhang J;Yuan J;Yuan Y;Zang X;Shen J;Lin S .Platelet adhesive resistance of segmented polyurethane film surface-grafted with vinyl benzyl sulfo monomer of ammonium zwitterions.[J].Biomaterials,2003(23):4223-4231. |
| [15] | Yuan YL;Ai F;Zang X P et al.Polyurethane vascu-lar catheter surface grated with zwitterionic sulfobetaine monomer activated by ozone[J].Colloids and Surfaces B:Biointerfaces,2004,35(01):1-5. |
| [16] | Yuan Jiang;Hou Qingfeng;Liu Baolei;Shen Jian;Lin Sicong .Platelet adhesive resistance of polyurethane surface grafted with zwitterions of sulfobetaine[J].Colloids and Surfaces, B. Biointerfaces,2004(1):19-26. |
| [17] | 廖白霞;李玉泉.乙二醇及聚乙二醇的酯化反应研究[J].高分子学报,1992(01):34-41. |
| [18] | 丘坤元;扬福良;黄祖.铈盐引发聚醚氨酯膜上丙稀酰胺接枝聚合反应[J].高分子通讯,1982(02):81-86. |
| [19] | 孙燕慧;丘坤元;冯新德.聚醚氨酯的氧化及其接枝共聚合的研究[J].高分子通讯,1983(02):3-9. |
| [20] | 秦玉军,全一武,张俊生,陈庆民.氨基硅油改性丁羟聚氨酯的合成与性能[J].南京大学学报(自然科学版),2002(02):205-210. |
| [21] | 全一武,倪寒立,张俊生,陈庆民.氨基硅油改性聚丁二烯聚氨酯脲的合成与性能[J].高分子材料科学与工程,2001(05):34-37. |
| [22] | 陈精华,刘伟区,宣宜宁,张斌.氨乙基氨丙基聚二甲基硅氧烷改性聚氨酯的研究[J].功能高分子学报,2004(01):92-96. |
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