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合成了一种具有精确分子结构的树枝状聚赖氨酸,并用1H-NMR & 13C-NMR和ESI-MS和MALDI-TOF MS等手段对所得产物结构进行了表征.通过不同条件实验的方法对树枝状聚赖氨酸的合成条件进行了优化.结果表明,反应温度、切割时间和溶剂对产率的影响明显.优化后的反应条件是原料配比为NDi-Boc-赖氨酸:N己二胺=2:1.0;冰水浴下反应2小时后温度升高至25℃继续反应24小时;保护基团切割时间为1.5小时.在优化的条件下,产物最高收率为80.2%.采用DMF作溶剂,效果优于DCM.

参考文献

[1] Zeng F W;Zimmerman S C .Dendrimers in SupramolecularChemistry:From Molecular Recognition to Self-Assembly[J].Chemical Reviews,1997,97:1681-1712.
[2] Frechet JMJ. .Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology [Review][J].Journal of Polymer Science, Part A. Polymer Chemistry,2003(23):3713-3725.
[3] Frechet J M J;Tomalia D A.Dendrimers and Other Dendritic Polymers[M].New York:Wiley,2001
[4] Grayson S M;Frechet J M J .Convergent dendrons and dendrimers:from synthesis to applications[J].Chemical Reviews,2001,01:3819-3868.
[5] Zloh M;Ramaswamy C;Sakthivel T;Wilderspin A;Florence AT .Investigation of the association and flexibility of cationic lipidic peptide dendrons by NMR spectroscopy[J].Magnetic Resonance in Chemistry: MRC,2005(1):47-52.
[6] Frank J. Feher;Kevin D. Wyndham .Amine and ester-substituted silsesquioxanes: synthesis, characterization and use as a core for starburst dendrimers[J].Chemical communications,1998(1):323-324.
[7] Loic Ropartz;Douglas F. Foster;Russell E.Morris;Alexandra M.Z.Slawin;David J.Cole-Hamilton .Hydrocarbonylation reactions using alkylphosphine-containing dendrimers based on a polyhedral oligosilsesquioxane core[J].Journal of the Chemical Society, Dalton Transactions.Inorganic Chemistry,2002(9):1997-2008.
[8] Hong B;Thoms T P S;Murfee H J;Lebrun M J .Highly branched dendritic macromolecules with core polyhedral silsesquioxane functionalities[J].Journal of Inorganic Chemistry,1997,36:6146-6147.
[9] Fields G B;Fields C G .Solvation effects in solid-phase peptide synthesis[J].Journal of the American Chemical Society,1991,113:4202-4207.
[10] Baigude H.;Katsuraya K.;Okuyama K.;Tokunaga S.;Uryu T. .Synthesis of sphere-type monodispersed oligosaccharide-polypeptide dendrimers[J].Macromolecules,2003(19):7100-7106.
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