合成了一种具有精确分子结构的树枝状聚赖氨酸,并用1H-NMR ＆ 13C-NMR和ESI-MS和MALDI-TOF MS等手段对所得产物结构进行了表征.通过不同条件实验的方法对树枝状聚赖氨酸的合成条件进行了优化.结果表明,反应温度、切割时间和溶剂对产率的影响明显.优化后的反应条件是原料配比为NDi-Boc-赖氨酸:N己二胺＝2:1.0;冰水浴下反应2小时后温度升高至25℃继续反应24小时;保护基团切割时间为1.5小时.在优化的条件下,产物最高收率为80.2%.采用DMF作溶剂,效果优于DCM.
参考文献
| [1] | Zeng F W;Zimmerman S C .Dendrimers in SupramolecularChemistry:From Molecular Recognition to Self-Assembly[J].Chemical Reviews,1997,97:1681-1712. |
| [2] | Frechet JMJ. .Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology [Review][J].Journal of Polymer Science, Part A. Polymer Chemistry,2003(23):3713-3725. |
| [3] | Frechet J M J;Tomalia D A.Dendrimers and Other Dendritic Polymers[M].New York:Wiley,2001 |
| [4] | Grayson S M;Frechet J M J .Convergent dendrons and dendrimers:from synthesis to applications[J].Chemical Reviews,2001,01:3819-3868. |
| [5] | Zloh M;Ramaswamy C;Sakthivel T;Wilderspin A;Florence AT .Investigation of the association and flexibility of cationic lipidic peptide dendrons by NMR spectroscopy[J].Magnetic Resonance in Chemistry: MRC,2005(1):47-52. |
| [6] | Frank J. Feher;Kevin D. Wyndham .Amine and ester-substituted silsesquioxanes: synthesis, characterization and use as a core for starburst dendrimers[J].Chemical communications,1998(1):323-324. |
| [7] | Loic Ropartz;Douglas F. Foster;Russell E.Morris;Alexandra M.Z.Slawin;David J.Cole-Hamilton .Hydrocarbonylation reactions using alkylphosphine-containing dendrimers based on a polyhedral oligosilsesquioxane core[J].Journal of the Chemical Society, Dalton Transactions.Inorganic Chemistry,2002(9):1997-2008. |
| [8] | Hong B;Thoms T P S;Murfee H J;Lebrun M J .Highly branched dendritic macromolecules with core polyhedral silsesquioxane functionalities[J].Journal of Inorganic Chemistry,1997,36:6146-6147. |
| [9] | Fields G B;Fields C G .Solvation effects in solid-phase peptide synthesis[J].Journal of the American Chemical Society,1991,113:4202-4207. |
| [10] | Baigude H.;Katsuraya K.;Okuyama K.;Tokunaga S.;Uryu T. .Synthesis of sphere-type monodispersed oligosaccharide-polypeptide dendrimers[J].Macromolecules,2003(19):7100-7106. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%