本工作研究了聚乙烯醇和羟基磷灰石复合型生物活性水凝胶,探讨了工艺条件和配方对其拉伸强度,压缩强度,粘弹性、润滑性等生物力学性能的影响,观察和比较了复合水凝胶的微观形貌.研究表明聚乙烯醇和羟基磷灰石可形成接近纳米级的均匀分散结构,良好相容,使复合凝胶的力学强度和润滑性能提高,其应力松弛性能更接近天然软骨的粘弹性.
参考文献
[1] | Nordin M;Frankel VH;过邦辅.临床骨科生物力学基础[M].上海:上海远东出版社,1993:57-60. |
[2] | Mayne R .Cartilage collagens:What is their function and are they involved in articular disease?[J].Arthritis and Rheumatism,1989,32:241. |
[3] | Dowson D;Disher J .Design Considerations for Cushion from Bearings In Artificial Hip Joints[J].Proceedings of the Institution of Mechanical Engineers,1991,205H:59. |
[4] | Ken S;Rick M .Polyurethane elastomer biostability[J].Journal of Biomedical Materials Research,1995,19:312. |
[5] | Hassan CM.;Peppas NA.;Ward JH. .Modeling of crystal dissolution of poly(vinyl alcohol) gels produced by freezing/thawing processes[J].Polymer: The International Journal for the Science and Technology of Polymers,2000(18):6729-6739. |
[6] | Razzak M T;Zainuddin;Erizal;DewiS.P et al.The characterization of dressing component materials and radiation foration of PVA-PVP hydrogel[J].Radiation Physics and Chemistry,1999,55:153. |
[7] | Razzak M T;Darwis D;Zainuddin;Sukirno .Irradiation of polyvinyl alcohol and polyvinyl pyrrolidone blends hydrogel for wound dressing[J].Radiation Physics and Chemistry,2001,62:107. |
[8] | 杨桂通.医用生物力学[M].北京:科学出版社,1994:114-121. |
[9] | Gu zhengqiu;Xiao Jiumei;Zhang Xianghong .The development of Artificial Cartilage PVA hydrogel[J].Biomedical Materials & Engineering,1998,8:75. |
[10] | Linn FC;Sokoloff L .Movement and composition of interstitial fluid of cartilage[J].Arthritis and Rheumatism,1985,8:481. |
[11] | 王以进;王介麟.骨科生物力学[M].北京:人民军医出版社,1989:209-220. |
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