羟基磷灰石对硅橡胶复合材料抗凝血性能的影响

材料科学与工程学报, 2003, 21(2): 162-164. doi: 10.3969/j.issn.1673-2812.2003.02.003

羟基磷灰石对硅橡胶复合材料抗凝血性能的影响

牟善松 ^1, , 屠美 ^2, , 汤顺清 ^3, , 周长忍 ^4,

1.暨南大学生物医学工程研究所,广州,510632

2.暨南大学生物医学工程研究所,广州,510632

3.暨南大学生物医学工程研究所,广州,510632

4.暨南大学生物医学工程研究所,广州,510632

基金项目: 国家自然科学基金(39770223)

关键词：羟基磷灰石 , 硅橡胶 , 血液相容性

Effect of Hydroxyapatite on the Blood Compatibility of Silicone Rubber Composite Materials

Keywords： hydroxyapatite , silicone , blood compatibility

本研究制备了在165℃×10min条件下交联的机械共混羟基磷灰石和硅橡胶生物材料,并通过动态凝血试验、溶血率测定、血小板粘附的SEM观察等方法评价了羟基磷灰石与硅橡胶复合材料的血液相容性.结果表明,含60%羟基磷灰石的复合材料血液相容性最佳.

Hydroxyapatite( HA)/ silicone rubber (SR) composite material was suggested to be used as biomaterials.In this paper, HA and SR were mixed by machine, and then crosslinked on the press vulcanizer at 165℃ for 10min. The relationship between the HA content in composite materials and blood compatibility was identified by the dynamic blood-clotting tests, haemolysis ratio measurement, platelet adhesion and SEM observation. The results show that the blood-compatibility of composite membranes with the concentration of HA 60% (wt) is more excellent than that of other HA/SR composite materials.

参考文献

[1]	R E Straith .[J].Plastic and Reconstructive Surgery,1999,88:1064-1067.
[2]	PKB Davis;SM Jones .[J].British Journal of Plastic Surgery,1971,24:405-407.
[3]	PD Waite et al.[J].Neurosurgery,1989,25:214-217.
[4]	MS Block et al.[J].International Journal of Oral and Maxillofacial Surgery,1989,17:358-262.
[5]	V Blitters;C Wijk et al.[J].Journal of Biomedical Materials Research,1990,24:433-436.
[6]	C Zhou;S Lin .[J].高分子材料科学与工程,1997,13(zk):110-112.
[7]	屠湘同,胡昕,李香梅,吴飞舟,周亮,林思聪.抗凝血生物材料的合成研究Ⅴ.聚醚氨酯表面肝素化的新途径[J].功能高分子学报,1995(02):209-212.
[8]	C Zhou;Z Yi .[J].Biomaterials,1999,20:2093-2097.

上一张下一张

计量

下载量()
访问量()

作者相关

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网