由于骨质疏松、骨折、骨肿瘤等原因导致的骨缺损困扰着世界上成千上万的人。近年来，关于骨缺损修复材料的研究已得到了国内外科研工作者的广泛关注。珍珠层是组成许多软体动物贝壳的结构单元之一。与骨组织类似，珍珠层也是一种由无机相矿物与有机基质组成的复合材料。虽然珍珠层与骨组织具有非同源性，但是，其部分的形成机理可能具有类似性。介绍了近年来国内外关于珍珠层研究的大量体外与体内试验，试验结果表明了珍珠层具有良好的生物相容性与成骨特性，有可能成为一种具有潜力的天然骨修复材料。珍珠层的成骨特性很有可能来源于其有机基质中的未知信号因子。同时也指出了珍珠层用作天然骨修复材料在今后研究中的机遇与挑战。
Bone loss due to osteoporosis, bone fracture, bone tumor and trauma affects hundreds of millions of people all over the world.Materials for the purpose of repairing bone defects have received extensive attention from many researchers at home and abroad in recent years.Nacre, which forms the inner layer of many mollusk shells, is also a composite of in-organic minerals and organic matrix similar to the structure of bone .Although nacre and bone are not homologous , parts of the complex machinery that directs their formation might be .Plenty of evidences of experiments about nacre both in vivo and in vitro in recent years are reviewed in this paper .The results present that nacre with its biocompatibility and osteo-genic property might be a potential natural biomaterial for bone regeneration .The osteogenic property of nacre might proba-bly be profited from some unknown signaling molecules within the organic matrix of nacre .Future perspectives and chal-lenges for nacre to be applied as a natural biomaterial for bone regeneration are also proposed finally .
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