功能化与高性能化的通用高分子材料在医用耗材及器械领域有着广泛的应用.作为重要的医用材料之一,血液相容性是首先需要解决的关键科学问题.通用高分子的血液相容性可通过化学和生物修饰来实现.采用的方法大体分为本体改性和表面改性.本体改性主要通过反应接枝和反应共混实现;而表面改性则主要通过在材料表面制备亲水性聚合物刷或亲水层、固定生物活性分子和形成生物仿生膜3种方法来实现.目前,生物材料的血液相容性研究主要集中在血浆蛋白吸附、血小板粘附和红细胞溶血3个方面.结合本课题组近期在生物医用材料领域的研究成果,简要介绍了国内外近年来通用高分子材料的化学和生物改性及其血液相容性研究进展.
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