光学探针是指与目标物质发生反应(包括配位、包合和基团反应等)并引起光学(吸光、荧光或发光)性质的变化,基于这些变化从而可对目标物质进行分析与测定的一类特殊试剂.光学探针不仅能改善分析的灵敏度,而且能大幅度提高对样品的时空分辨能力,因此,长期以来一直受到人们的关注.试卤灵为一性能优良的荧光体,特别是其7-羟基的取代作用通常会封闭光信号;这一特性近年引起了人们的兴趣,并被广泛用于构建具有低背景光信号的新型探针.本文将综述试卤灵类光学探针的发展及其在蛋白酶、离子、活性氧物种分析方面的应用,包括探针分子的构筑、检测机理以及生物成像等方面的研究.
参考文献
| [1] | Shi, W.;Ma, H. .Spectroscopic probes with changeable π-conjugated systems[J].Chemical communications,2011(70):8732-8744. |
| [2] | li X H;Gao X H;Shi W.Design strategies for water-soluble small molecular chromogenic and fluorogenic probes[J].Chemical Reviews,2013 |
| [3] | 邱波,于天君,陈金平,曾毅,李嫕.水相氟离子“turn-on”型荧光传感器[J].影像科学与光化学,2013(05):383-389. |
| [4] | 胡睿,郭旭东,杨国强.激发态分子内质子转移化合物的性能及作为荧光化学传感器的应用研究[J].影像科学与光化学,2013(05):335-348. |
| [5] | Ha Na Kim;Zhiqian Guo;Weihong Zhu .Recent progress on polymer-based fluorescent and colorimetric chemosensors[J].Chemical Society Reviews,2011(1):79-93. |
| [6] | Chen XQ;Sun M;Ma HM .Progress in spectroscopic probes with cleavable active bonds[J].Current organic chemistry,2006(4):477-489. |
| [7] | Bueno C.;Villegas ML.;Bertolotti SG.;Previtali CM.;Neumann MG. Encinas MV. .The excited-state interaction of resazurin and resorufin with amines in aqueous solutions. Photophysics and photochemical reaction[J].Photochemistry and Photobiology: An International Journal,2002(4):385-390. |
| [8] | Zhang, Y.;Chen, W.;Feng, D.;Shi, W.;Li, X.;Ma, H. .A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging[J].The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry,2012(3):716-721. |
| [9] | 宋延超,刘俊秀,张阳阳,史文,马会民.纳米材料在生物分析应用中存在的若干问题[J].化学学报,2013(12):1607-1610. |
| [10] | Aaron E. Albers;Katherine A. Rawls;Christopher J. Chang .Activity-based fluorescent reporters for monoamine oxidases in living cells[J].Chemical communications,2007(44):4647-4649. |
| [11] | Zhao Li;Xiaohua Li;Xinghui Gao;Yangyang Zhang;Wen Shi;Huimin Ma .Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one[J].Analytical chemistry,2013(8):3926-3932. |
| [12] | Li, Z.;Gao, X.;Shi, W.;Li, X.;Ma, H. .7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase[J].Chemical communications,2013(52):5859-5861. |
| [13] | Hofmann J;Sernetz M .Immobilized enzyme kinetics analyzed by flow-through microfluorimetry:resorufin-β-D-galactopyranoside as a new fluorogenic substrate for β-galactosidase[J].Analytica Chimica Acta,1984,163:67-72. |
| [14] | Motabar, O.;Shi, Z.-D.;Goldin, E.;Liu, K.;Southall, N.;Sidransky, E.;Austin, C.P.;Griffiths, G.L.;Zheng, W. .A new resorufin-based α-glucosidase assay for high-throughput screening[J].Analytical Biochemistry: An International Journal of Analytical and Preparative Methods,2009(1):79-84. |
| [15] | Gao W;Xing B;Tsien R Y et al.Novel fluorogenic substrates for imaging lactamase gene expression[J].Journal of the American Chemical Society,2003,125:11146-11147. |
| [16] | Luke D. Lavis;Tzu-Yuan Chao;Ronald T. Raines .Synthesis and utility of fluorogenic acetoxymethyl ethers[J].Chemical science,2011(3):521-530. |
| [17] | Cui, K.;Chen, Z.;Wang, Z.;Zhang, G.;Zhang, D. .A naked-eye visible and fluorescence "turn-on" probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells[J].The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry,2011(1):191-195. |
| [18] | Sun M.;Shangguan D.;Ma HM.;Nie LH.;Li XH.;Xiong SX.;Liu GQ. Thiemann W. .Simple Pb-II fluorescent probe based on Pb-II-catalyzed hydrolysis of phosphodiester[J].Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies,2003(6):413-420. |
| [19] | Ma, X.;Wang, J.;Shan, Q.;Tan, Z.;Wei, G.;Wei, D.;Du, Y. .A "turn-on" fluorescent Hg ~(2+) chemosensor based on ferrier carbocyclization[J].Organic letters,2012(3):820-823. |
| [20] | Ren, W.X.;Pradhan, T.;Yang, Z.;Cao, Q.-Y.;Kim, J.S. .Rapid responsive palladium sensor under mild condition[J].Sensors and Actuators, B. Chemical,2012(0):1277-1282. |
| [21] | Soon Young Kim;Jong-ln Hong .Chromogenic and Fluorescent Chemodosimeter for Detection of Fluoride in Aqueous Solution[J].Organic letters,2007(16):3109-3112. |
| [22] | Chen, W.;Li, Z.;Shi, W.;Ma, H. .A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation[J].Chemical communications,2012(22):2809-2811. |
| [23] | Choi, MG;Cha, S;Park, JE;Lee, H;Jeon, HL;Chang, SK .Selective Perborate Signaling by Deprotection of Fluorescein and Resorufin Acetates[J].Organic letters,2010(7):1468-1471. |
| [24] | Choi, M.G.;Hwang, J.;Eor, S.;Chang, S.-K. .Chromogenic and fluorogenic signaling of sulfite by selective deprotection of resorufin levulinate[J].Organic letters,2010(24):5624-5627. |
| [25] | 陈巍,马会民.检测活性氧物种的氧杂蒽类光学探针的研究进展[J].分析化学,2012(09):1311-1321. |
| [26] | Miller E W;Tulyathan O;Isacoff E Y et al.Molecular imaging of hydrogen peroxide produced for cell signaling[J].Nature Chemical Biology,2007,3:263-267. |
| [27] | Gerald L.Newton;Jamie R.Milligan .Fluorescence detection of hydroxyl radicals[J].Radiation Physics and Chemistry,2006(4):473-478. |
| [28] | Zhang Y Y;Shi W;Li X H et al.Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal[J].Scientific Reports,2013,3:2830. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%