通过亲电取代反应成功合成了磺化聚醚砜并制备了聚醚砜/磺化聚醚砜共混膜.膜的水吸附量和水接触角实验表明,和单纯的聚醚砜膜相比,由于磺酸基的存在使得共混膜的亲水性得到提高.牛血清蛋白吸附实验结果显示:与聚醚砜膜相比,共混膜能有效地抑制牛血清蛋白的吸附.凝血时间实验则表明,聚醚砜/磺化聚醚砜共混膜的凝血时间比纯聚醚砜膜的凝血时间延长了2～3倍,因而共混膜的血液相容性较纯聚醚砜膜得到提高.
The sulfonated polyethersulfone (SPES) was synthesized through an electrophilic substitution reaction and PES/SPES blending membranes were prepared. The water adsorption and contact angle(CA) experiments show that the hydrophilicity of PES/SPES blend membrane is improved as for the sulfonate group existing in the SPES. BSA adsorption experiment shows that PES/SPES blend membranes can inhibit the protein adsorption effectively compared with PES membrane. Blood coagulation time experiment shows that the times of PES/SPES blend membranes are 2～3 times than that of PES membrane. So the blood compatibility of blend membranes is improved compared with pure PES membrane.
参考文献
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