纳米材料具有表面效应、小尺寸效应、量子尺寸效应、宏观量子效应等特殊性质,在社会生产和生活中有广阔的应用前景,其对人体健康及环境的潜在影响已引起科学界及政府部门的关注.综述了大量常见的人工纳米粒子,包括碳纳米材料、纳米氧化物、纳米金属单质等的生物和毒理学国内外研究成果,比较了这些材料的毒理行为,分析了其生物毒性的产生机理,并展望了纳米粒子生物安全性研究的可能方向.
参考文献
| [1] | 夏萍萍,郭新彪.纳米材料安全性的国内外研究动向[J].中国职业医学,2007(05):423-424,429. |
| [2] | 常雪灵,邢更妹,孙宝云.纳米技术的生物环境健康效应与相应的标准研究[J].中国标准化,2007(09):18-20. |
| [3] | Cui D;Tian F;Ozkan CS;Wang M;Gao H .Effect of single wall carbon nanotubes on human HEK293 cells.[J].Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research,2005(1):73-85. |
| [4] | Carrero-Sanchez JC;Elias AL;Mancilla R;Arrellin G;Terrones H;Laclette JP;Terrones M .Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen[J].Nano letters,2006(8):1609-1616. |
| [5] | 景连东,向婵,廖美芳,饶凯敏,信丽丽.碳纳米管对小鼠肝和肺细胞DNA损伤的彗星实验研究[J].医学研究杂志,2007(09):25-29,封3. |
| [6] | Hirano S;Kanno S;Furuyama A .Multi-walled carbon nanotubes injure the plasma membrane of macrophages.[J].Toxicology and Applied Pharmacology,2008(2):244-251. |
| [7] | 晏晓敏,石宝友,王东升,汤鸿霄.纳米富勒烯（nC60）的生态毒性效应[J].化学进展,2008(02):422-428. |
| [8] | Eva Oberdorster .Manufactured Nanomaterials (Fullerenes,C_(60)) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass[J].Environmental Health Perspectives,2004(10):1058-1062. |
| [9] | Jia G;Wang HF;Yan L;Wang X;Pei RJ;Yan T;Zhao YL;Guo XB .Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene[J].Environmental Science & Technology: ES&T,2005(5):1378-1383. |
| [10] | 肖琳,付聪,梁思斯,毛彩霞,袭著革,杨旭.纳米SiO2与常规SiO2颗粒对Hela细胞的细胞毒性作用[J].生态毒理学报,2007(04):435-439. |
| [11] | Nishimori H;Kondoh M;Isoda K .Silica nanoparticles as hepatotoxicants.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2009(3):496-501. |
| [12] | 王江雪,李炜,刘颖,劳芳,陈春英,樊瑜波.二氧化钛纳米材料的环境健康和生态毒理效应[J].生态毒理学报,2008(02):105-113. |
| [13] | Edilberto B;James B M;Brian A W et al.Pulmonary responses of mice,rats,and hamsters to subchronic nhalation of ultrafine titanium dioxide particles[J].Toxicological Sciences,2004,77:347. |
| [14] | Kerstin Hund-Rinke;Markus Simon .Ecotoxic Effect of Photocatalytic Active Nanoparticles (TiO_2) on Algae and Daphnids[J].Environmental Science and Pollution Research,2006(4):225-232. |
| [15] | Wang J G;Zhang X Z;Chen Y S et al.Toxicity assessment of manufactured nanomaterials using the unicellular greenalga chlamydmnonas reinhardtii[J].Chemosphere,2008,73(07):1121. |
| [16] | Sayes CM;Wahi R;Kurian PA;Liu Y;West JL;Ausman KD;Warheit DB;Colvin VL .Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells.[J].Toxicological sciences: An official journal of the Society of Toxicology,2006(1):174-185. |
| [17] | 陈克正,胡迎花.纳米磁性氧化铁粒子对HeLa及HEK293细胞的毒理作用研究[J].纳米科技,2007(02):8-11,50. |
| [18] | 李志勇,苟云久,杨永珠,谢二庆.三氧化二铁纳米磁流体对小鼠心肺组织的氧化损伤[J].中国组织工程研究与临床康复,2008(32):6279-6282. |
| [19] | Zhu MT;Feng WY;Wang B;Wang TC;Gu YQ;Wang M;Wang Y;Ouyang H;Zhao YL;Chai ZF .Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats.[J].Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems,2008(2/3):102-111. |
| [20] | 刘子宏,王翔,王海芳,王天成,顾依群,闫蕾,杨胜韬,许君辉,赵晓红,杜仙梅,臧嘉捷,肖硕,贾光.气管滴注纳米氧化锌对小鼠的急性毒性作用[J].环境与职业医学,2008(04):360-364. |
| [21] | 杨辉,杨丹凤,张华山,张伟,刘焕亮,刘超,袭著革.4种典型纳米材料对小鼠胚胎成纤维细胞毒性的初步研究[J].生态毒理学报,2007(04):427-434. |
| [22] | 刘红云,白伟,张智勇,胡友彪,赵宇亮,刘年庆.纳米氧化物对斑马鱼胚胎孵化率的影响[J].中国环境科学,2009(01):53-57. |
| [23] | 徐兰举,赵景霞,刘仕昌,张涛,REN Guo-gang,杨卓.纳米氧化铜对大鼠海马神经元Ik电流和PC12细胞活性的影响[J].生物物理学报,2008(02):123-128. |
| [24] | Oesterling E;Chopra N;Gavalas V;Arzuaga X;Lim EJ;Sultana R;Butterfield DA;Bachas L;Hennig B .Alumina nanoparticles induce expression of endothelial cell adhesion molecules.[J].Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research,2008(3):160-166. |
| [25] | 孟幻,陈真,赵宇亮.部分纳米材料的纳米生物学效应研究[J].基础医学与临床,2006(07):699-703. |
| [26] | 傅凤,刘振乾,陈传红.纳米铜粉对浮游植物生长的影响[J].生态科学,2007(02):126-130. |
| [27] | 王天成,汪冰,丰伟悦,贾光,沈惠麒,赵宇亮.纳米锌对小鼠血清生化指标的影响[J].中国公共卫生,2006(08):934-935. |
| [28] | Nadine Pernodet;Xiaohua Fang;Yuan Sun;Asya Bakhtina;Aditi Ramakrishnan;Jonathan Sokolov;Abraham Ulman;Miriam Rafailovich .Adverse Effects of Citrate/Gold Nanoparticles on Human Dermal Fibroblasts[J].Small,2006(6):766-773. |
| [29] | Hussain SM;Hess KL;Gearhart JM;Geiss KT;Schlager JJ .In vitro toxicity of nanoparticles in BRL 3A rat liver cells.[J].Toxicology in vitro: an international journal published in association with BIBRA,2005(7):975-983. |
| [30] | 丁峰,宋文华,白茹,刘艳,张文佳,张金洋,高敏苓.纳米铁材料对小鼠肺灌洗液中白细胞和羟脯氨酸的影响[J].南开大学学报（自然科学版）,2008(03):1-4. |
| [31] | 孙皎,丁婷婷.纳米羟基磷灰石颗粒对巨噬细胞DNA的损伤[J].中国组织工程研究与临床康复,2008(01):15-18. |
| [32] | 刘芳,何晓晓,王柯敏,葛佳,谭蔚泓.硅壳纳米颗粒对COS-7细胞的生物效应[J].高等学校化学学报,2007(10):1857-1862. |
| [33] | Dhawan A;Taurozzi JS;Pandey AK;Shan WQ;Miller SM;Hashsham SA;Tarabara VV .Stable colloidal dispersions of C-60 fullerenes in water: Evidence for genotoxicity[J].Environmental Science & Technology: ES&T,2006(23):7394-7401. |
| [34] | Christie M.Sayes;John D.Fortner;Wenh Guo .The Differential Cytotoxicity of Water-Soluble Fullerenes[J].Nano letters,2004(10):1881-1888. |
| [35] | Sayes CM;Gobin AM;Ausman KD;Mendez J;West JL;Colvin VL .Nano-C-60 cytotoxicity is due to lipid peroxidation[J].Biomaterials,2005(36):7587-7595. |
| [36] | 景连东,王红蕾,饶凯敏,信丽丽.碳纳米管毒理学研究进展[J].中国水运（理论版）,2007(08):86-87. |
| [37] | Li SQ;Zhu RR;Zhu H .Nanotoxicity of TiO(2) nanoparticles to erythrocyte in vitro.[J].Food and Chemical Toxicology,2008(12):3626-3631. |
| [38] | Laura K. Adams;Delina Y. Lyon;Pedro J.J. Alvarez .Comparative eco-toxicity of nanoscale TiO_2, SiO_2, and ZnO water suspensions[J].Water research: A journal of the international water association,2006(19):3527-3532. |
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