废弃蚕茧中提取并制得易溶性丝胶蛋白(SS)粉末,玉米淀粉(MS)作填充剂,与PVA经水相共混和反复冻融制备了不同配比SS/PVA/MS复合凝胶膜。经红外检测对其结构进行了确认;分别以去离子水和模拟体液(SBF)为介质,考察了SS/PVA质量比及MS含量对膜材料力学性能、溶胀性和降解性的影响。结果显示SS/PVA质量比为3/7,MS含量为18%时,膜的断裂伸长率为最优,拉伸强度可达到较优水平,而通过对MS含量和SS/PVA质量比的调整,可以达到调节复合膜降解速率的目的。
Silk sericin(SS) was extracted from waste cocoon and a series of composite gel-film(CGF) was prepared using SS,polyvinyl alcohol(PVA),maize starch(MS),etc.by aqueous phase blending and repeatedly freeze-thaw.IR spectroscopy confirmed the blending structure of CGF.In dissolved medium of deionized water and simulated body liquid(SBF),the SS/PVA mass ratio and MS content effect on the mechanical property,swelling ratio(SR),dissolved ratio(DR) of CGF were investigated,respectively.The tensile-strength of CGF was good and its break-elongation can be to achieve optimal when SS/PVA was 3/7 and MS content was 18%.The degradation rate of CGF can be regulated with the adjustment of SS/PVA mass ratio and MS content.
参考文献
[1] | 刘凤兴,程为庄.生物可降解高分子材料及其在药物释放中的应用[J].高分子通报,2004(06):38-41,67. |
[2] | 顾伟,刘雷艮,左保齐.天然生物可降解材料在生物医学领域中的应用[J].苏州大学学报(工科版),2006(01):69-73. |
[3] | 张雨青.丝胶蛋白的药理及其在医用材料上的应用[J].纺织学报,2003(03):98-100. |
[4] | 陈华,朱良均,闵思佳,胡国梁.蚕丝丝胶蛋白的结构、性能及利用[J].功能高分子学报,2001(03):344-348. |
[5] | 郭大刚,徐可为.聚乙烯醇在生物医学工程中的应用研究进展[J].生物医学工程学杂志,2005(03):602-605. |
[6] | 高洋,冯屏,田晓慧,闫伟.以柠檬酸作交联剂改善丝胶/聚乙烯醇热固化膜的性能[J].蚕业科学,2010(01):91-96. |
[7] | 王群,齐鲁.硼酸改性丝胶-聚乙烯醇膜的性能[J].纺织学报,2008(07):6-8,12. |
[8] | 李文涛,唐颂超.生物降解性高分子材料[J].上海塑料,2002(01):3-8. |
[9] | Kokubo T;Takadama H .How useful is SBF in predicting in vivo bone bioactivity?[J].Biomaterials,2006(15):2907-2915. |
[10] | 许俊,江学良,孙康.聚乙烯醇/丝胶共混凝胶薄膜的制备与表征[J].功能高分子学报,2007(04):369-373. |
- 下载量()
- 访问量()
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%