The preparation method of urethral extracellular matrix (ECM) was introduced and the biocompatibility of urethral ECM was studied. The urethral segmental defect was created artificially in animal models, which were followed by reconstruction with prepared urethral ECM. And postoperative histologic and pathologic exams were employed to evaluate the biocompatibility of urethral ECM. The experimental results show that urethral ECM was biocompatible and can promote cellular interaction as well as tissue development. Urethrography and urodynamic evaluation revealed that there was no difference between the normal and new tissue. The urethral ECM appears to be a useful material for urethral repair in the rabbit. It is biocompatible and for tissue handling.
参考文献
| [1] | Atala A .Regenerative Medicine and Urology[J].BJU International,2003,92(zk):58-67. |
| [2] | Shin H;Jo S;Mikos AG .Biomimetic materials for tissue engineering.[J].Biomaterials,2003(24):4353-4364. |
| [3] | Kim B S;Baez C E;Atala A .Biomaterials for Tissue Engineering[J].World Journal of Urology,2000,18:2-9. |
| [4] | 杨嗣星,宋超,刘勇,金化民,王玲珑,詹炳炎.尿道细胞外基质的研制[J].中华泌尿外科杂志,2003(08):555-557. |
| [5] | Kleinman HK;Philp D;Hoffman MP .Role of the extracellular matrix in morphogenesis.[J].Current Opinion in Biotechnology,2003(5):526-532. |
| [6] | Sievert K D;Tanagho E A .Organ-specific Acellular Matrix for Reconstruction of the Urinary Tract[J].World Journal of Urology,2000,18:19-25. |
| [7] | Atala A .Tissue Engineering for the Replacement of Organ Function in the Genitourinary System[J].American Journal of Transplantation,2004,4(zk):58-73. |
| [8] | Wakatsuki T;Elson EL .Reciprocal interactions between cells and extracellular matrix during remodeling of tissue constructs.[J].Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena,2003(1/3):593-605. |
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