以生物可降解材料聚乳酸-羟基乙酸(PLGA)为载体制备了载紫杉醇纳米粒,重点考察了纳米粒的体外释放特性.采用乳化-溶剂挥发法制备了载紫杉醇PLGA纳米粒,其平均粒径为200nm,载药量为21%,包封率为89.44%;体外释药符合Higuchi方程:Q=3.8796t1/2+30.4649(r=0.9397),同时载紫杉醇纳米粒具有一定的缓释作用.
Paclitaxel loaded nanoparticles are prepared using biodegradable materials poly(lactic-co-glycolic acid)(PLGA) as drug carrier, with an emphasis on the release behavior study of the nanoparticles in vitro. Paclitaxel loaded PLGA nanoparticles are made by emulsion(O/W)-solvent evaporation process. The mean size, drug loading, encapsulation efficiency of paclitaxel loaded PLGA nanoparticles are 200nm, 21 %, 89. 44% respectively. The in vitro release properties can be expressed by the Higuchi's equation Q=3. 8796t1/2 +30. 4649(r=0. 9397) ,and paclitaxel loaded PLGA nanoparticles show sustained release.
参考文献
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