以生物活性SiO2-CaO-P2O5-CaF2系统玻璃粉末为基体,以磷酸铵溶液为固化液,添加明胶微球,制得了明胶微球多孔玻璃基骨水泥.将骨水泥于置37℃的生理模拟液(SBF)中浸泡后,利用pH计、XRD、SEM和力学试验机等对浸泡液的pH值和钙离子浓度,以及浸泡产物的晶相、显微结构和力学性能等进行了观测和分析.结果表明,明胶微球的加入使玻璃基骨水泥从高pH值降至略大于7.0的弱碱性,并加快了骨水泥对钙离子的吸收和羟基磷灰石(HAP)的生长,使玻璃基骨水泥体现出更好的生物活性.在明胶微球含量为5%(质量分数)时,浸泡后形成的骨水泥的孔隙率接近80%,而其抗压强度仍可达5 MPa以上.
参考文献
[1] | Nishimura N;Yamamuro T et al.A new bioactive bone cement:Its histological and mechanical characterization[J].Journal of Applied Biomaterials,1991,2(04):135. |
[2] | Tamura J et al.Bioactive bone cement:The effect of amours of glass powder and histologic change with time[J].Journal of Biomedical Materials Research,1995,29(04):551. |
[3] | Shinzato S;Kobayashi M;Mousa WF;Kamimura M;Neo M;Kitamura Y;Kokubo T;Nakamura T .Bioactive polymethyl methacrylate-based bone cement: comparison of glass beads, apatite- and wollastonite-containing glass-ceramic, and hydroxyapatite fillers on mechanical and biological properties.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2000(2):258-272. |
[4] | Shinzato S et al.Bioactive bone cement:Effect of filler size on mechanical properties and osteoconductivity[J].Journal of Biomedical Materials Research,2001,56(03):452. |
[5] | 周萘,黄文旵.自硬性玻璃基生物水泥的制备[J].玻璃与搪瓷,1998(01):6. |
[6] | 付强,周萘,黄文旵,王德平,张丽英.玻璃基生物骨水泥内部纳米羟基磷灰石的形成研究[J].功能材料,2004(03):376-378,382. |
[7] | Draye JP;Delaey B;Van-de-Voorde A;Van-Den-Bulcke A;Bogdanov B;Schacht E .In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films.[J].Biomaterials,1998(1/3):99-107. |
[8] | Yan C et al.Anticancer gelatin microspheres with multiple functions[J].BIOMATERIALS,1991,12(07):640. |
[9] | Silvio L D;Gurav N;Kayser M V et al.Biodegradable microspheres:A new delivery system for growth hormone[J].BIOMATERIALS,1994,15(11):931. |
[10] | Draye JP;Delaey B;Van-de-Voorde A;Van-Den-Bulcke A;De-Reu B;Schacht E .In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films.[J].Biomaterials,1998(18):1677-1687. |
[11] | Choi YS;Hong SR;Lee YM;Song KW;Park MH;Nam YS .Studies on gelatin-containing artificial skin: II. Preparation and characterization of cross-linked gelatin-hyaluronate sponge.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1999(5):631-639. |
[12] | Zhao F;Yin Y;Lu WW;Leong JC;Zhang W;Zhang J;Zhang M;Yao K .Preparation and histological evaluation of biomimetic three-dimensional hydroxyapatite/chitosan-gelatin network composite scaffolds.[J].Biomaterials,2002(15):3227-3234. |
[13] | Yaylaoglu MB;Korkusuz P;Ors U;Korkusuz F;Hasirci V .Development of a calcium phosphate-gelatin composite as a bone substitute and its use in drug release.[J].Biomaterials,1999(8):711-719. |
[14] | Chun-Hsu Yao;Jui-Sheng Sun;Feng-Huei Lin;Chun-Jen Liao;Chin-Wang Huang .Biological effects and cytotoxicity of tricalcium phosphate and formaldehyde cross-linked gelatin composite[J].Materials Chemistry and Physics,1996(1):6-14. |
[15] | Bigi A;Bracci B;Panzavolta S .Effect of added gelatin on the properties of calcium phosphate cement.[J].Biomaterials,2004(14):2893-2899. |
[16] | 翟羽佳,蔡舒,周维,李许东.磷酸钙骨水泥/明胶微球复合支架的力学性能[J].硅酸盐学报,2010(08):1568-1572. |
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