采用W/O乳液法,在不同条件下,用Ca2+交联和戊二醛交联制备了羧甲基纤维素(CMC)-海藻酸钠(SA)复合微球. SEM结果显示,当m(CMC)∶m(SA)=1∶5、温度为60℃时,球形较好.采用FT-IR分析了复合微球的化学结构.对复合微球的溶胀率、药物包封率进行表征,结果显示复合微球在磷酸缓冲液中的溶胀率达到700％,且溶胀速度快.该复合微球对当归(ASD)具有较好的缓释作用.
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