剪切流动下细胞吸附、滚动和脱附的物理机理对理解相关体内生物过程和发展体外微流体技术非常重要.已有研究集中于匀速流动下细胞吸附过程,而加速流动广泛存在于体内和体外流动,但加速流动对细胞吸附及脱附的影响及机理尚不清楚.我们采用界面追踪法研究了加速流动下细胞的滚动及脱附行为.结果表明;1)相对匀速流动,加速流动下细胞更难发生滚动和脱附;2)加速度越小,细胞变形越大,细胞发生滚动和脱附的临界壁面应力也越大.
参考文献
| [1] | Jian Chen;Jason Li;Yu Sun .Microfluidic approaches for cancer cell detection, characterization, and separation[J].Lab on a chip,2012(10):1753-1767. |
| [2] | Sunitha Nagrath;Lecia V. Sequist;Shyamala Maheswaran;Daphne W. Bell;Daniel Irimia;Lindsey Ulkus;Matthew R. Smith;Eunice L. Kwak;Subba Digumarthy;Alona Muzikansky .Isolation of rare circulating tumour cells in cancer patients by microchip technology[J].Nature,2007(7173):1235-1239. |
| [3] | Z. Y. LUO;F. XU;T. J. LU;B. F. BAI .DIRECT NUMERICAL SIMULATION OF DETACHMENT OF SINGLE CAPTURED LEUKOCYTE UNDER DIFFERENT FLOW CONDITIONS[J].Journal of mechanics in medicine and biology,2011(2):273-284. |
| [4] | BOFENG BAP;ZHENGYUAN LUO;TIANJIAN LU;FENG XU .NUMERICAL SIMULATION OF CELL ADHESION AND DETACHMENT IN MICROFLUIDICS[J].Journal of mechanics in medicine and biology,2013(1):1350002-1350002. |
| [5] | Yuan Wan;Jifa Tan;Waseem Asghar .Velocity Effect on Aptamer-Based Circulating Tumor Cell Isolation in Microfluidic Devices[J].The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical,2011(47):13891-13896. |
| [6] | Luthur Siu Lun Cheung;Xiangjun Zheng;Ashley Stopa .Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel[J].Lab on a chip,2009(12):1721-1731. |
| [7] | Bo Feng Bai;Zheng Yuan Luo;Shu Qi Wang;Long He;Tian Jian Lu;Feng Xu .Inertia effect on deformation of viscoelastic capsules in microscale flows[J].Microfluidics and nanofluidics,2013(5):817-829. |
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