采用粉末冶金法制备了Ti/HA复合材料,对其体内生物活性进行了研究。植入早期,纯Ti种植体周围有一层纤维组织形成,纤维膜随着种植时间的延长逐渐消失,并伴随有新骨形成,植入6个月后,纯Ti与周围骨组织之间形成典型的骨接触界面。含钛量为30％的复合材料周围在植入早期有很薄一层新骨形成,种植体与周围骨组织之间存在很大的空隙,含钛量为50％和70％的复合材料周围则有大量的新骨形成,植入6个月后三种复合材料均与周围骨组织之间形成了牢固的骨性结合界面。可见,三种Ti/HA复合材料均具有良好的生物活性。但含钛量为30％的复合材料成骨速度明显低于另两种复合材料。三种Ti/HA复合材料的生物活性均大于纯Ti。
Ti/HA biocomposites were successfully fabricated by the powder metallurgy method. The in vivo
bioactivities of the biocomposites were investigated. At an early stage of implantation, a fibrous film forms around the pure titanium
implant. And with the increase of implantation time, the fibre tissue disappears gradually, accompanying the formation of new bone. After
6-month implantation, a typical bone-contact interface forms between the pure titanium implant and the surrounding bone. A very
thin film of new bone is observed around the composite with 30% titanium and a big gap exists between the composite and the surrounding
bone at an early stage of implantation, whereas, large quantity of new bone forms around the composites with 50% and 70% titanium. These
three composites all form tight bone-bonding interface with the surrounding bone after 6-month implantation. So it can be concluded
that these Ti/HA composites all exhibit excellent bioactivity. The osteogenic rate of the composite with 30% titanium is distinctly
lower than that of the other two Ti/HA composites. The three Ti/HA composites all have better bioactivity than pure titanium.
参考文献
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