交联聚乙烯醇(CPVA)微球是一种生物相容性聚合物微球,利用其表面大量的羟基,与铈盐构成氧化还原引发体系,实现了甲基丙烯酸(MAA)的表面引发接枝聚合,制备了接枝微球CPVA-g-PMAA.采用红外光谱(FT-IR)法、扫描电子显微镜(SEM)及zeta电位测定等法,对接枝微球的化学结构及物理化学特性进行了表征.初步考察了接枝微球CPVA-g-PMAA对代谢分子肌酐(Cr)及药物分子5-氟尿嘧啶(5-FU)的吸附性能,分析了吸附机理.实验结果表明,较大的pH值范围内,接枝微球CPVA-g-PMAA的zeta电位为绝对值较大的负值,即其表面携带高密度的负电荷.受静电相互作用的驱动,接枝微球CP-VA-g-PMAA对含N的Cr及5-FU分子表现出很强的吸附能力.
参考文献
| [1] | Wen X F;He H Y;Lee L J .[J].Journal of Immunological Methods,2009,350(1-2):97-105. |
| [2] | Müller-Schuhen D;Hodenius M .[J].Radiation Physics and Chemistry,2002,63(3-6):513-516. |
| [3] | Fundueanu G;Constantin M;Ascenzi P .Poly(vinyl alcohol) microspheres with pH- and thermosensitive properties as temperature-controlled drug delivery.[J].Acta biomaterialia,2010(10):3899-3907. |
| [4] | Zouani,O.F.;Chollet,C.;Guillotin,B.;Durrieu,M.-C. .Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides[J].Biomaterials,2010(32):8245-8253. |
| [5] | Nho Y C;Kwon O H .[J].Radiation Physics and Chemistry,2003,66(04):299-307. |
| [6] | Li F;Li J;Zhang SS .Molecularly imprinted polymer grafted on polysaccharide microsphere surface by the sol-gel process for protein recognition[J].Talanta: The International Journal of Pure and Applied Analytical Chemistry,2008(5):1247-1255. |
| [7] | Udrea L E;Hritcu D;Popa M I et al.[J].Journal of Magnetism and Magnetic Materials,2011,323(01):7-13. |
| [8] | Sharma KV;Dreher MR;Tang Y;Pritchard W;Chiesa OA;Karanian J;Peregoy J;Orandi B;Woods D;Donahue D;Esparza J;Jones G;Willis SL;Lewis AL;Wood BJ .Development of "imageable" beads for transcatheter embolotherapy.[J].Journal of vascular and interventional radiology,2010(6):865-876. |
| [9] | Borovac T;Pelage JP;Kasselouri A;Prognon P;Guiffant G;Laurent A .Release of ibuprofen from beads for embolization: In vitro and in vivo studies[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(3):266-274. |
| [10] | Semiz Oysu A;Moustafa T;Cho K J .[J].European Journal of Radiology Extra,2007,64(03):99-102. |
| [11] | 刘苏宇,高保娇,付红艳.接枝聚合-大分子反应法在交联聚乙烯醇微球表面接枝聚偕胺肟的研究[J].高分子学报,2010(06):727-733. |
| [12] | Arslan H;Hazer B .[J].European Polymer Journal,1999,35(08):1451-1455. |
| [13] | Tsai H A;Syu M J .[J].Analytica Chimica Acta,2005,539:107-116. |
| [14] | Akhdar H;Loyer P;Rauch C .Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells.[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR),2009(12):2219-2227. |
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