基于飞行时间技术的PET发展历史与现状

原子核物理评论 , 2012, 29(2): 162-168.

基于飞行时间技术的PET发展历史与现状

贠明凯 ^1, , 李婷 ^2, , 章志明 ^3, , 张玉包 ^4, , 单保慈 ^5, , 魏龙 ^6,

基金项目: 国家自然科学基金资助项目(10775149,10805049)

History and Current Status of PET Devolopment based on Time of Flight

Keywords： PET , TOF , TOF imaging reconstruction , image quality

简要介绍了基于飞行时间（Time of Flight,简称TOF）技术的正电子发射断层扫描成像（Posi-tron Emission Tomography,简称PET）的基本原理,回顾了TOF-PET成像设备的发展历史,讨论了影响TOF-PET时间分辨率的主要因素,并对TOF-PET给图像重建技术带来的挑战进行了分析。最后,重点介绍了TOF-PET技术所带来的优势,使用TOF技术可以有效地改善图像质量,并且为临床诊断和临床前研究带来便利。

The principle of time of flight （TOF） positron emission tomography （PET） and a brief review of the history of TOF-PET are introduced. The factors influencing the time resolution of a TOF-PET scanner are presented, especially focus on the intrinsic properties of scintillators and front-end electronics. Challen- ges and achievements of the structure of data organization and image reconstruction are reviewed. Finally, the benefits of TOF-PET on image quality improvement and tumor detection are emphasized.

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