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利用扫描电镜、X射线衍射仪、红外漫反射仪,以及对β-磷酸三钙/聚乳酸组织工程支架在模拟体液(SBF)中失重率和模拟体液pH值的变化的测试,系统研究了聚乳酸组织工程支架在模拟体液中的降解和矿化性能。结果发现,随着β-磷酸三钙/聚乳酸组织工程支架在模拟体液中浸泡时间的增长,模拟体液的pH值有下降趋势;支架材料的质量是降解和矿化作用共同影响的结果。X射线衍射图谱和红外光谱(FT-IR)漫反射图谱研究表明,浸在SBF中的支架表面有磷灰石沉积物出现,且沉积物与β-磷酸三钙的晶型相似。

We systematically studied the degradable performance and bio-mineralization function of β-tricalcium phosphate/poly(lactic acid) tissue engineering scaffolds in simulated body fluid(SBF) by measuring pH value of SBF,the lost weight ratio of scaffolds and analyzing scanning electron microscope(SEM) pictures,X-ray diffraction(XRD) and Fourier transform infrared spectra(FT-IR) of scaffolds' surface.We found that in SBF,the pH value of SBF with scaffolds decreases with the prolongation of time.However,the weight of scaffolds does not always decrease with the prolongation of time.The XRD and FT-IR show that there appears the deposition of bone-like carbonate hydroxyl apatite on the surface of the scaffolds and the structure of the deposition is similar to the structure of β-tricalcium phosphate(TCP).

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