采用物理共混法,制备PvA/sA/GT的三元复合凝胶微球,用于盐酸四环素的包载和药物的释放研究.选择5:5:2、5:5:3和5:5:4三种比例制备的微球,研究在模拟胃液和肠液的条件(空白微球对照)下,GT量和pH变化对释药性能和降解性能的影响.结果表明:5:5:4比例相变的微球的释药性能和降解性能都最好;模拟胃液较模拟肠液能加快微球的降解,进而加速微球的释药速率;是否栽药对微球的降解性能无影响,但是微球的降解会加速微球的释药速率.
参考文献
| [1] | 李瑞欣,张西正,赵家森,武继民,郭勇.聚乙烯醇/海藻酸钠复合水凝胶的制备及电场响应性能[J].高分子材料科学与工程,2003(06):160-163. |
| [2] | 刘根起,赵晓鹏.明胶-海藻酸钠半互穿聚合物网络膜及其电刺激响应行为的研究[J].功能材料,2003(04):473-475,478. |
| [3] | Almeida PF;Almeida AJ .Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(3):431-439. |
| [4] | Zhang Xianzheng;Zhuo Renxi;Cui Jingzhou et al.A-novel thermo-responsive drug delivery system with positive controlled release[J].International Journal of Pharmaceutics,2002,235:43. |
| [5] | Bos GW;Jacobs JJ;Koten JW;Van Tomme S;Veldhuis T;van Nostrum CF;Den Otter W;Hennink WE .In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy.[J].European journal of pharmaceutical sciences,2004(4):561-567. |
| [6] | He HY;Cao X;Lee LJ .Design of a novel hydrogel-based intelligent system for controlled drug release[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(3):391-402. |
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