新型可生物降解两性pH敏感水凝胶的制备与性能研究

材料导报, 2010, 24(14): 48-51.

新型可生物降解两性pH敏感水凝胶的制备与性能研究

彭辉 ^1, , 罗彦凤 ^2, , 孙姣霞 ^3, , 吴进川 ^4,

1.重庆大学生物工程学院生物材料与仿生工程中心,生物流变科学与技术教育部重点实验室,重庆,400044

2.重庆大学生物工程学院生物材料与仿生工程中心,生物流变科学与技术教育部重点实验室,重庆,400044

3.重庆大学生物工程学院生物材料与仿生工程中心,生物流变科学与技术教育部重点实验室,重庆,400044

4.重庆大学生物工程学院生物材料与仿生工程中心,生物流变科学与技术教育部重点实验室,重庆,400044

基金项目: 重庆自然科学基金(CSTC2006BB5010) 国家自然科学基金(30970700)

关键词： pH敏感水凝胶 , 可生物降解 , 乙二胺四乙酸酐 , 丁二胺 , 氨基封端聚乙二醇

Synthesis and Characterization of a Novel Biodegradable Amphoteric pH-sensitive Hydrogel

以乙二胺四乙酸酐(EDTAD)和丁二胺(BDA)为原料,通过酸酐的N-酰化开环反应得到侧链只含羧基的直链共聚物PEB-COOH,然后用N-羟基丁二酰亚胺(NHS)和二环己基碳二亚胺(DCC)活化PEB-COOH中的羧基,以重均分子量为500的氨基封端聚乙二醇(ATPEG500)为交联剂,制得单体间连接全部为酰胺键、侧链只含羧基的交联网络聚合物PEB-ATPEG500-COOH.pH敏感性测试表明,PEB-ATPEG500-COOH具有3个pH敏感范围,分别是pH=2～4、pH=6～7和pH=10～11,表现出明显的两性pH敏感性.研究了该水凝胶在37℃条件下分别在pH=2、7、11介质中的溶胀动力学,并对溶胀速率进行了详细分析.该网络聚合物可望成为一种集完全可降解性、pH敏感性和生物相容性于一身的新型两性pH敏感水凝胶.

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