应用静电纺丝技术，以Captopril（CPL）为模型药物，以聚（乳酸-羟基乙酸）（PLGA）为载体高分子材料制备CPL／PLGA载药纳米纤维。探讨了静电纺丝工艺参数，得出最佳较优纺丝条件为原液浓度20％（质量分数），载药量：m（CPL）：m／（PLGA）=2：10，电压12．5kV，流速1mL／h，溶剂为V（二氯甲烷）：V（丙酮）=2：1。应用扫描电子显微镜（SEM）、傅立叶红外光谱仪（FT-IR）、差示扫描量热仪（DSC）和采用多晶衍射仪（XRD）对所制备的载药纤维进行了表征。体外（Invitro）释药性研究实验结果表明，PLGA载药纳米纤维具有明显的初期突释，随着缓冲溶液pH值增加，初期突释减弱，药物释放度也会随之减弱。
Ultrafine captopril(CPL)-loaded poly(lactic-co-glycolic acid) (PLGA) fibers were successfully pre-pared by electrospinning method from co-dissolving solutions of PLGA and Captopril in dichloromethane (DMC) .acetone(ACT)(2 : 1) that was made as the spinning solutions. The optimal spinning parameters wereobtained that was PLGA 20wt%, m (CPL) : m (PLGA) = 2:10, voltage : 12.5kV, the rate : lmL/h, the ratio of solvent : V(DCM) : V(ACT)=2 : 1. The samples thereby obtained were characterized by scanning electronmicroscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), differential scanning caborimetry) (DSC) and X-ray diffraction (XRD) measurements. In vitro release study showed that a sustained release wasachieved after a burst release at the early stage. The burst release and overall drug was reduced as the pH ofbuffer solution increased.
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