以高强可降解掺锶磷灰石骨水泥(Sr-HAC)为原料,以快速成型(RP)宏孔可控树脂为模板,合成了由掺锶磷灰石(Sr-HA)、掺锶磷酸钙(Sr-TCP)组成的新型双相掺锶磷酸钙(Sr-BCP)骨支架.结果表明,Sr-BCP骨支架相组成可根据Sr-HAC的(Ca+Sr)/P比率予以调控.骨支架宏孔高度连通,孔径400～550 μm,且宏孔壁上具有丰富的微孔(孔径2～5 μm).此外,骨支架宏孔参数可通过设计不同孔结构的负模予以反向调控.宏孔百分数与相组成对Sr-BCP支架的抗压强度与降解速率有重要影响.与BCP骨支架相比,Sr-BCP骨支架具有更高的强度及更快的降解速率,一定程度上缓解了BCP陶瓷骨支架在力学和降解性能上难以兼顾的矛盾.
参考文献
| [1] | Gauthier O;Bouler JM;Aguado E;Pilet P;Daculsi G .Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth.[J].Biomaterials,1998(1/3):133-139. |
| [2] | Christoffersen J;Christoffersen M R;Kolthoff N .[J].Bone,1997,20:47. |
| [3] | Guo DG;Xu KW;Zhao XY;Han Y .Development of a strontium-containing hydroxyapatite bone cement[J].Biomaterials,2005(19):4073-4083. |
| [4] | Takasi S;Chow L C .[J].Journal of Materials Science:Materials in Medicine,2001,12:135. |
| [5] | Raynaud S;Champion E;Lafon JP;Bernache Assollant D .Calcium phosphate apatites with variable Ca/P atomic ratio III. Mechanical properties and degradation in solution of hot pressed ceramics.[J].Biomaterials,2002(4):1081-1089. |
| [6] | Lerous L;Lacout J L .[J].Journal of Materials Research,2001,16:171. |
| [7] | Almirall A.;Larrecq G.;Delgado JA.;Martinez S.;Planell JA.;Ginebra MP. .Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an alpha-TCP paste[J].Biomaterials,2004(17):3671-3680. |
| [8] | Galois L;Mainard D;Bordji K.[J].Actualités en Biomatériaux,1996(03):361. |
| [9] | Kalita S J;Bose S;Hosick H L et al.[J].Mater Sic & Eng C,2003,23:611. |
| [10] | Yuan H P;Kurashina K J;Bruijin J D et al.[J].Biomaterials,1999,20:1799. |
| [11] | Ramay H R;Zhang M .[J].BIOMATERIALS,2003,24:3292. |
| [12] | Giesen E B W;Ding M;Dalstra M et al.[J].Journal of Biomechanics,2001,34:799. |
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