采用化学共沉淀法制得羟基磷灰石(HAP)粉和铝镁尖晶石(Spinel)粉,并以HAP粉体和Spinel粉体为原料采用粉末冶金方法制得HAP·TCF-Spinel复合生物材料。采用红外光谱分析、X射线衍射、透射电镜、扫描电镜、金相、力学性能测试和蛋白质吸附实验等对上述合成的材料进行了表征。微观结构表明HAP·TCP与Spinel两相分布均匀,且界面结合良好。该复合材料具有良好的抗弯强度(σ抗弯)和抗压强度(σ抗压)。当HAP的含量为62.5wt％时其抗弯强度和抗压强度分别达到σ抗弯=212MPa,σ抗压=352MPa。蛋白质吸附实验表明,HAP·TCP-S-Spinel复合生物材料对白蛋白和血清蛋白具有较强的吸附能力。
Ca10(PO4)6(OH)2·Ca2(PO4)3-MgAl2O4 (HAP·TCP-Spinel) composite biomaterials were synthesized by chemical
deposition and followed by powder metallurgy technique. Microstructures were characterized by fourier transform infrared spectroscopy
(FTIR), X-ray diffraction(XRD), scan electron microscopy(SEM), and transmission electron microscopy(TEM). TEM observation shows that a perfect
combination is presented in the interface between HAP crystals and Spinel crystals. The effects of composition on mechanical properties
investigated show that the highest compressive strength and bending strength are σb=212MPa and σt=352MPa respectively, matching
the composition of 62.5wt% of HAP in the composite. Similar to HAP, the composite is available to adsorb serum protein and albumin protein, though the amount of protein adsorption
on the surface of the composite is significantly less than that on surface of HAP.
参考文献
| [1] | Tadashi K, Hyun M K, Masakazu K. Biomaterials, 2003, 24: 2161--2175. [2] 黄志良, 王大伟, 刘羽, 等. 武汉化工学院学报, 2001, 3: 49--53. [3] 刘羽, 钟康年, 胡文云, 等. 材料科学与工程, 1997, 15 (1): 63--65. [4] 王志强, 马铁成, 韩趁涛, 等. 无机盐工业, 2001, 33 (1): 3--5. [5] Wojciech S, Masatomo Y, Masato K, et al. Biomaterials, 1996, 17: 1715--1723. [6] Yasuda Y H, Mahara S, Umakoshi Y, et al. Biomaterials, 2000, 21: 2045--2049. [7] Atsuo I, Haruo K, Makoto O, et al. Materials Science and Engineering, 2002, 22: 21--25. [8] Yun M S, Dae H K. Journal of Crystal Growth, 2003, 254: 411--417. [9] Yaszemski J M, Payne G R, Hayes C W, et al. Biomaterials, 1996, 17: 175--185. [10] With D G, Dijk V, Hattu N, et al. Mater Sci., 1981, 16: 1592--1598. [11] Jarcho M, Bolen H C, Thomas B M, et al. Mater Sci., 1976, 11: 2027--2035. [12] 翁文杰, 董天华, 陈贤志, 等. 江苏医药, 1995, 21 (10): 677--678. [13] 王迎军, 刘康时, 司徒朴, 等. 华南理工大学学报, 1995, 23 (5): 1--5. [14] Kalcec T E, Sauer M, Nonninger R, et al. J. Mat. Sci., 2001, 36: 5253--5263. [15] Kurzweg H, Heimann B R, Troczynski T, et al. Biomaterials, 1998, 19: 1507--1511. [16] 黄志良, 王大伟, 刘羽, 等. 武汉化工学院, 2001, 23 (3): 49--53. [17] Ruan Jian-ming. Characterization and Biocompatibility Evaluation of Materials in vifro PHDthises[M]. Glasgon Universty, England, 1998. 135--161. [18] Lowry O, Roseblough N. J. Biol. Chem, 1951, 193: 265--275. [19] Dasarathy H, Riley C, Coble H, et al. J. Biomed. Mater. Res, 1993, 27 (4): 477--482. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%