甘草次酸(β)海藻酸钠-羧甲基壳聚糖复合凝胶珠的制备及体外释放

材料导报, 2012, 26(18): 77-80.

甘草次酸(β)海藻酸钠-羧甲基壳聚糖复合凝胶珠的制备及体外释放

钟大根 ^1, , 刘宗华 ^2, , 黄彧琛 ^3, , 施云峰 ^4, , 张奕 ^5, , 薛巍 ^6,

1.暨南大学生命与健康工程研究院药物载体实验室,广州510632

2.暨南大学生命与健康工程研究院药物载体实验室,广州510632

3.暨南大学生命与健康工程研究院药物载体实验室,广州510632

4.暨南大学生命与健康工程研究院药物载体实验室,广州510632

5.暨南大学生命与健康工程研究院药物载体实验室,广州510632

6.暨南大学生命与健康工程研究院药物载体实验室,广州510632

基金项目: 广东省自然科学基金(S2011010004545) 广州市科技计划基金(2010J-E271) 广州天河区科技计划项目(104ZH084;096G126)

关键词：海藻酸钠 , 水凝胶 , 羧甲基壳聚糖 , 甘草次酸 , 疏水性药物

Preparation and in Vitro Release of Alginate-carboxymethyl Chitosan composite Hydrogel Beads for 18β-Glycyrrhetinic Acid Delivery

以海藻酸钠-羧甲基壳聚糖(ALG--CMC)为载体材料,甘草次酸(β)(GA)为模型药物,采用滴制法制备了ALG-CMC负载GA的复合凝胶珠.采用体视显微镜与扫描电镜(SEM)观察了凝胶珠的外观形貌,考察了凝胶珠的溶胀性能和体外释药行为,以及CaCl2浓度对凝胶珠的包封率和载药量的影响.结果表明,湿态凝胶珠形态规整、粒径分布均匀,平均粒径约2900μm,包封率最高达85.7％,载药量为18.0％；CaCl2浓度对包封率和载药量几乎无影响；在pH=1.2的HCl溶液中凝胶珠溶胀率小、累积释放率低；在pH=7.4的磷酸盐缓冲(PBS)溶液中凝胶珠溶胀率大、累积释放率高.滴制法制备ALG-CMC凝胶珠条件温和、不接触有机溶剂,凝胶珠具有pH敏感性且能有效载药.该体系有可能成为GA的给药载体材料.

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