以引发剂量的壳聚糖(CS)为母体骨架,通过与丙烯酰胺(AM)和丙烯酸(AA)连续的自由基聚合反应,制备了一种全亲水丙烯酰胺/丙烯酸类梳型聚合物(CSPAM/PAA).聚合物中丙烯酰胺和丙烯酸的组成比例可通过控制反应时间调节,并可通过核磁共振碳谱定量计算.该聚合物具有全亲水嵌段共聚物的特性,在水溶液中具有良好的pH响应性和离子响应性.聚合物溶于水并在酸性条件下自组装形成囊泡结构的聚集体,多价金属离子(如Tb3+离子)也可以引起聚合物的响应聚集.
参考文献
| [1] | Onaca, O;Enea, R;Hughes, DW;Meier, W .Stimuli-Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery[J].Macromolecular bioscience,2009(2):129-139. |
| [2] | David Diaz Diaz;Dennis Kuhbeck;Rudy J. Koopmans .Stimuli-responsive gels as reaction vessels and reusable catalysts[J].Chemical Society Reviews,2011(1):427-448. |
| [3] | MacEwan SR;Callahan DJ;Chilkoti A .Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.[J].Nanomedicine,2010(5):793-806. |
| [4] | George Pasparakis;Maria Vamvakaki .Multiresponsive polymers: nano-sized assemblies, stimuli-sensitive gels and smart surfaces[J].Polymer chemistry,2011(6):1234-1248. |
| [5] | Yuelong Sun;Zhiping Peng;Xinxing Liu .Synthesis and pH-sensitive micellization of doubly hydrophilic poly(acrylic acid)-b-poly(ethylene oxide)-b-poly (acrylic acid) triblock copolymer in aqueous solutions[J].Colloid and polymer science,2010(8):997-1003. |
| [6] | Shen, YH;Zhang, XY;Lu, JJ;Zhang, AQ;Chen, K;Li, XQ .Effect of chemical composition on properties of pH-responsive poly(acrylamide-co-acrylic acid) microgels prepared by inverse microemulsion polymerization[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2009(1/3):87-90. |
| [7] | Zhang YX;Wu FP;Li MZ;Wang EJ .pH switching on-off semi-IPN hydrogel based on cross-linked poly(acrylamide-co-acrylic acid) and linear polyallyamine[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(18):7695-7700. |
| [8] | Sondjaja HR;Hatton TA;Tam KC .Self-assembly of poly(ethylene oxide)-block-poly(acrylic acid) induced by CaCl2: Mechanistic study[J].Langmuir: The ACS Journal of Surfaces and Colloids,2008(16):8501-8506. |
| [9] | Tatiana K.Bronich;Paul A.Keifer;Luda S.Shlyakhtenko;Alexander V.Kabanov .Polymer Micelle with Cross-Linked Ionic Core[J].Journal of the American Chemical Society,2005(23):8236-8237. |
| [10] | Agut, W.;Br?let, A.;Schatz, C.;Taton, D.;Lecommandoux, S. .PH and temperature responsive polymeric micelles and polymersomes by self-assembly of poly[2-(dimethylamino)ethyl methacrylate]- b -poly(glutamic acid) double hydrophilic block copolymers[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(13):10546-10554. |
| [11] | Boudier A;Aubert Pouessel A;Gerardin C;Devoisselle JM;Begu S .pH-sensitive double-hydrophilic block copolymer micelles for biological applications.[J].International Journal of Pharmaceutics,2009(2):212-217. |
| [12] | Cheng C;Wei H;Shi BX;Cheng H;Li C;Gu ZW;Cheng SX;Zhang XZ;Zhuo RX .Biotinylated thermoresponsive micelle self-assembled from double-hydrophilic block copolymer for drug delivery and tumor target[J].Biomaterials,2008(4):497-505. |
| [13] | Liu, O.;Wang, L.;Schork, F.J. .Synthesis of well-defined statistical and diblock copolymers of acrylamide and acrylic acid by inverse miniemulsion raft polymerization[J].Macromolecular chemistry and physics,2010(18):1977-1983. |
| [14] | Taton D;Wilczewska A Z;Destarac M .Direct synthesis of double hydrophilic statistical di-and triblock copolymers comprised of acrylamide and acrylic acid units via the MADIX process[J].Mac romol Rapid Commun,2001,22:1497-1503. |
| [15] | 张玉玺,吴飞鹏,李妙贞,王尔(钅监).模板聚合法合成P（AM/AA）多嵌段共聚物的溶液性质和自缔合作用[J].高分子学报,2006(05):666-670. |
| [16] | Feng Qian;Fuying Cui;Jieying Ding .Chitosan Graft Copolymer Nanoparticles for Oral Protein Drug Delivery: Preparation and Characterization[J].Biomacromolecules,2006(10):2722-2727. |
| [17] | Truong N D;Galin J C;Francois J .Microstructure of acrylamide-acrylic acid copolymers:2.as obtained by direct copolymerization[J].Polymer,1986,27:467-475. |
| [18] | Truong N D;Galin J C;Francois J .Microstructure of acrylamide-acrylic acid copolymers:1.as obtained by alkaline hydrolysis[J].Polymer,1986,27:459-466. |
| [19] | Schilli CM;Zhang MF;Rizzardo E;Thang SH;Chong YK;Edwards K;Karlsson G;Muller AHE .A new double-responsive block copolymer synthesized via RAFT polymerization: Poly(N-isopropylacrylamide)-block-poly(acrylic acid)[J].Macromolecules,2004(21):7861-7866. |
| [20] | Xue, YN;Huang, ZZ;Zhang, JT;Liu, M;Zhang, M;Huang, SW;Zhuo, RX .Synthesis and self-assembly of amphiphilic poly(acrylic acid-b-DL-lactide) to form micelles for pH-responsive drug delivery[J].Polymer: The International Journal for the Science and Technology of Polymers,2009(15):3706-3713. |
| [21] | Deng, L;Wang, CH;Li, ZC;Liang, DH .Re-examination of the "Zipper Effect" in Hydrogen-Bonding Complexes[J].Macromolecules,2010(6):3004-3010. |
| [22] | Garces F O;Sivadasan K;Somasundaran P et al.Interpolymer complexation of poly(acrylic acid) and poly (acrylamide):structural and dynamic studies by solution-and solids-state NMR[J].Macromolecules,1994,27:272-278. |
| [23] | Sivadasan K;Somasundaran P;Turro N J .Fluorescence and viscometry study of complexation of poly(acrylic acid) with poly(acrylamide) and hydrolyzed poly(acrylamide)[J].Colloid and Polymer Science,1991,269:131-137. |
| [24] | Sivadasan K;Somasundaran P .Complexation of hydrolyzed poly(acrylamide) with poly(acrylic acid) by excimer fluorescence measurements of pyrene labeled polymers[J].Journal of Polymer Science Part A:Polymer Chemistry,1991,29:911-914. |
| [25] | 方云;王婷;林海江 等.一种由丙烯酰胺-丙烯酸共聚物制备片状大复合囊泡的方法[P].中国专利,101591444,2011-06-22. |
| [26] | Nicolas Sanson;Frederic Bouyer;Corine Gerardin;Martin In .Nanoassemblies formed from hydrophilic block copolymers and multivalent ions[J].Physical Chemistry Chemical Physics,2004(7):1463-1466. |
| [27] | 李振泉,张玉玺,曹绪龙,宋新旺,王胜蓝,王尔梃,吴飞鹏.水溶液中P（AM-co-PEBA）聚合物对Tb3+离子荧光增强作用[J].化学学报,2009(11):1243-1246. |
| [28] | Zhu L Y;Tong X F;Li M Z et al.Luminescence enhancement of Tb3+ ion in assemblies of amphiphilic lineardendritic block copolymers:antenna and microenvironment effects[J].Journal of Physical Chemistry B,2001,105:24612464. |
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