欢迎登录材料期刊网

材料期刊网

高级检索

简述了智能水凝胶在药物控释系统中的应用及国内外研究进展.重点阐述了高分子水凝胶中的pH敏感、温敏、电场敏感、光敏感水凝胶和小分子水凝胶的结构、性质.以及作为释药载体在给药系统中的研究应用.

参考文献

[1] Samchenko, Y.;Ulberg, Z.;Korotych, O. .Multipurpose smart hydrogel systems[J].Advances in colloid and interface science,2011(1/2):247-262.
[2] Singh A;Sharma P K;Garg V K et al.Hydrogels:A review[J].Int J Pharrnaceut Sci Rev Res,2010,4(02):97.
[3] 廖列文,刘正堂,岳航勃,崔英德.电场敏感智能水凝胶的研究进展[J].化工进展,2008(11):1750-1755.
[4] Hydrogels in Controlled Drug Delivery Systems[J].Iranian polymer journal,2009(1):63-88.
[5] Bhattarai N;Gunn J;Zhang M .Chitosan-based hydrogels for controlled,localized drug delivery[J].Advanced Drug Delivery Reviews,2010,62(01):83.
[6] Pan, T.-T.;He, W.-D.;Li, L.-Y.;Jiang, W.-X.;He, C.;Tao, J. .Dual thermo- and pH-sensitive network-grafted hydrogels formed by macrocrosslinker as drug delivery system[J].Journal of Polymer Science, Part A. Polymer Chemistry,2011(10):2155-2164.
[7] Almeida, J.F.;Ferreira, P.;Lopes, A.;Gil, M.H. .Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2011(5):948-954.
[8] 张高奇 .海藻酸钠/聚(N-异丙基丙烯酰胺)pH/温度敏感水凝胶的制备及结构与性能的研究[D].东华大学,2004.
[9] Hazem El-Sherif;Mansour El-Masry;Manal F. Abou Taleb .pH-Sensitive Hydrogels Based on Bovine Serum Albumin for Anticancer Drug Delivery[J].Journal of Applied Polymer Science,2010(4):2050-2059.
[10] Anna A. Barba;Annalisa Dalmoro;Felice De Santis .Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery[J].Polymer bulletin,2009(5):679-688.
[11] Meng Yang,Bo-tian Liu,Ge Gao,Xiao-li Liu,Feng-qi Liu.POLY(MALEIC ANHYDRIDE-CO-ACRYLIC ACID)/POLY(ETHYLENE GLYCOL) HYDROGELS WITH pH-AND IONIC-STRENGTH-RESPONSES[J].高分子科学(英文版),2010(06):951-959.
[12] Slawomir Kadlubowski;Artur Henke;Piotr Ulanski .Hydrogels of polyvinylpyrrolidone (PVP) and poly(acrylic acid) (PAA) synthesized by radiation-induced crosslinking of homopolymers[J].Radiation Physics and Chemistry,2010(3):261-266.
[13] Manavi-Tehrani, I.;Rabiee, M.;Parviz, M.;Tahriri, M.R.;Fahimi, Z..Preparation, characterization and controlled release investigation of biocompatible pH-sensitive PVA/PAA hydrogels[J].Macromolecular symposia,2010:457-465.
[14] Zhang Y;Wei W;Lv P;Wang L;Ma G .Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2011(1):11-19.
[15] Liu ZH;Jiao YP;Zhang ZY .Calcium-carboxymethyl chitosan hydrogel beads for protein drug delivery system[J].Journal of Applied Polymer Science,2007(5):3164-3168.
[16] Yang X;Kim JC .Novel pH-sensitive microgels prepared using salt bridge.[J].International Journal of Pharmaceutics,2010(1/2):58-63.
[17] 许雅菁,范冰,马敬红,梁伯润.羧甲基纤维素钠/聚(N-异丙基丙烯酰胺)纳米复合水凝胶的制备及结构性能表征[J].功能高分子学报,2007(01):44-48.
[18] 赵骞 .多孔智能水凝胶的合成与性能[D].浙江大学,2009.
[19] Lin YH;Liang HF;Chung CK;Chen MC;Sung HW .Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs.[J].Biomaterials,2005(14):2105-2113.
[20] George M;Abraham TE .pH sensitive alginate-guar gum hydrogel for the controlled delivery of protein drugs.[J].International Journal of Pharmaceutics,2007(1/2):123-129.
[21] Park SE.;Nho YC.;Lim YM.;Kim HI. .Preparation of pH-sensitive poly(vinyl alcohol-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogels by gamma ray irradiation and their insulin release behavior[J].Journal of Applied Polymer Science,2004(1):636-643.
[22] Wood KM;Stone GM;Peppas NA .The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models.[J].Acta biomaterialia,2010(1):48-56.
[23] Konstantinos Pagonis;Georgios Bokias .Upper critical solution temperature-type cononsolvency of poly(N,N-dimethylacrylamide) in water-organic solvent mixtures[J].Polymer: The International Journal for the Science and Technology of Polymers,2004(7):2149-2153.
[24] Dinarvand R;D' Emanuele A .The use of thermoresponsive hydrogels for on-off release of molecules[J].Journal of Controlled Release,1995,36(03):221.
[25] H. Y. Liu;X. X. Zhu .Lower critical solution temperatures of N-substituted acrylamide copolymers in aqueous solutions[J].Polymer: The International Journal for the Science and Technology of Polymers,1999(25):6985-6990.
[26] LI-YING LI;WEI-DONG HE;JIAN LI;SHOU-CHEN HAN;XIAO-LI SUN;BO-YU ZHANG .Synthesis of Twin-Tail Tadpole-Shaped Hydrophilic Copolymers and Their Thermo-Responsive Behavior[J].Journal of Polymer Science, Part A. Polymer Chemistry,2009(24):7066-7077.
[27] Zhu Peng Wei;Napper Donald H. .Aggregation of block copolymer microgels of poly(N-isopropylacrylamide) and poly(ethylene glycol)[J].Macromolecules,1999(6):2068-2070.
[28] Ruel Gariepy E;Leroux JC .In situ-forming hydrogels-review of temperature-sensitive systems.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2004(2):409-426.
[29] Zhang J.;Peppas NA. .Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks[J].Macromolecules,2000(1):102-107.
[30] 滕大勇 .氨基糖类衍生物智能水凝胶作为药物载体的研究[D].南开大学,2009.
[31] Swietach P;Vaughan-Jones RD;Harris AL .Regulation of tumor pH and the role of carbonic anhydrase 9.[J].Cancer and Metastasis Reviews,2007(2):299-310.
[32] Shim WS;Kim JH;Kim K;Kim YS;Park RW;Kim IS;Kwon IC;Lee DS .pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel.[J].International Journal of Pharmaceutics,2007(1):11-18.
[33] Qiu Y;Park K .Environment-sensitive hydrogels for drug delivery[J].Advanced Drug Delivery Reviews,2001,53(03):321.
[34] Kim S Y;Shin H S;Lee Y M et al.Properties of electroresponsive poly (vinyl alcohol)/poly (acrylic acid) IPN hydrogels under an electric stimulus[J].Journal of Applied Polymer Science,1999,73(09):1675.
[35] Kim SJ.;Park SJ.;Kim IY.;Shin MS.;Kim SI. .Electric stimuli responses to poly(vinyl alcohol)/chitosan interpenetrating polymer network hydrogel in NaCl solutions[J].Journal of Applied Polymer Science,2002(9):2285-2289.
[36] Gajbhiye N D;Kadam V J;Jadhav K R et al.Pulsatile drug delivery system[J].Journal of Pharmacy Practice and Research,2010,3(01):120.
[37] Kouichi Sutani;Isao Kaetsu;Kumao Uchida .The synthesis and the electric-responsiveness of hydrogels entrapping natural polyelectrolyte[J].Radiation Physics and Chemistry,2001(1):49-54.
[38] Daniel J. Schmidt;Joshua S. Moskowitz;Paula T. Hammond .Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating[J].Chemistry of Materials: A Publication of the American Chemistry Society,2010(23):6416-6425.
[39] 金淑萍,柳明珠,陈世兰,卞凤玲,陈勇,王斌,詹发禄,刘守信.智能高分子及水凝胶的响应性及其应用[J].物理化学学报,2007(03):438-446.
[40] 张新房.智能水凝胶[J].食品与药品A,2005(03):17-22.
[41] Carmen Alvarez-Lorenzo;Lev Bromberg;Angel Concheiro .Light-sensitive Intelligent Drug Delivery Systems[J].Photochemistry and Photobiology: An International Journal,2009(4):848-860.
[42] Lin HM;Wang WK;Hsiung PA;Shyu SG .Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass.[J].Acta biomaterialia,2010(8):3256-3263.
[43] Zhang K.;Wu XY. .Modulated insulin permeation across a glucose-sensitive polymeric composite membrane[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2002(1/3):169-178.
[44] 张书第,翟玉春,张振芳.PVA/Fe2O3磁敏感性水凝胶的制备及性能[J].过程工程学报,2010(02):405-408.
[45] 相梅,郑志伟,汪辉亮,贺昌城.磁场敏感性水凝胶研究进展[J].高分子通报,2010(03):16-22.
[46] 郑超,高如瑜,张玉奎.分子印迹技术在生物大分子分离识别中的应用[J].色谱,2006(03):309-314.
[47] Rimantas Kublickas;Carsten Werner;Giedre Jariene .Polyacrylamide gels containing ionized functional groups for the molecular imprinting of human growth hormone[J].Polymer bulletin,2007(3):611-617.
[48] de Loos M;Feringa B L;van Esch J H.Design and application of self-assermbled low molecular weight hydrogels[J].European Journal of Organic Chemistry,2005(17):3615.
[49] Shi N E;Dong H;Yin G et al.A smart supramoleeular hydrogel exhibiting pH-modulated viscoelastic properties[J].Advanced Functional Materials,2007,17(11):1837.
[50] 马丽霞 .Fmoc保护的二肽小分子水凝胶的研究[D].山东大学,2008.
[51] ZHIMOU YANG;GAOLIN LIANG;BING XU .Enzymatic Hydrogelation of Small Molecules[J].Accounts of Chemical Research,2008(2):315-326.
[52] Jiban J.Panda;Aseem Mishra;Atanu Basu .Stimuli Responsive Self-Assembled Hydrogel of a Low Molecular Weight Free Dipeptide with Potential for Tunable Drug Delivery[J].Biomacromolecules,2008(8):2244-2250.
[53] Naskar J;Pal.ui G;Banerjee A .Tetrapeptide-based hydrogels:For encapsulation and slow release of an anticancer drug at physiological pH[J].Journal of Physical Chemistry B,2009,113(35):11787.
[54] Friggeri A;Feringa BL;van Esch J .Entrapment and release of quinoline derivatives using a hydrogel of a low molecular weight gelator[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(2):241-248.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%