聚苹果酸及其衍生物是一类新型的生物高分子材料,具有良好的生物降解性和生物相容性.介绍了聚苹果酸及其衍生物的结构和性能特点,综述了它们的合成方法的研究进展,并展望了它们在药物载体及生物医用材料等领域的应用前景.
参考文献
| [1] | 戈进杰.生物降解高分子材料及其应用[M].北京:化学工业出版社,2002 |
| [2] | Vert M. .Chemical routes to poly(beta-malic acid) and potential applications of this water-soluble bioresorbable poly(beta-hydroxy alkanoate)[J].Polymer Degradation and Stability,1998(1/3):169-175. |
| [3] | Lee B-S;Vert M;Holler E .Water-soluble aliphatic polyesters:poly(malic acid)s[J].Biopolymers,2002,3:75. |
| [4] | Arnold S;Lenz R .Synthesis of stereoregular poly(alkyl malolactonates)[J].Macromolecular Symposia,1986,6:285. |
| [5] | Cammas S;Renard I;Boutault K et al.A novel synthesis of optically active4-benzyloxy-and-4-alkyloxycarbonyl-2-oxetanones[J].Tetrahedron:Asymmetry,1993,4(08):1925. |
| [6] | Kajiyama T;Kobayashi H;Taguchi T .Improved synthesis with high yield and increased molecular weight of poly(α,β-malic acid)by direct polycondensation[J].Biomacromolecules,2004,5(01):169. |
| [7] | Vert M;Lenz R W .Preparation and properties of poly-β-malic acid:a functional polyester of potential biomedical importance[J].Polymeric Preprints(American Chemical Society Division of Polymer Chemistry),1979,20(01):608. |
| [8] | Guerin Ph;Vert M;Braud C .Optically active poly(β-malic acid)[J].POLYMER BULLETIN,1985,14(02):187. |
| [9] | Guerin Ph;Francillete J;Braud C et al.Benzyl esters of optically active malic acid stereocopolymers as obtained by ring-opening polymerization of(R)-(+)-and(S)-(-)-benzyl malolactonates[J].Macromolecular Symposia,1986,6:305. |
| [10] | Cammas S.;Langlois V.;Guerin P.;Renard I. .POLY(BETA-MALIC ACID) - OBTAINING HIGH MOLECULAR WEIGHTS BY IMPROVEMENT OF THE SYNTHESIS ROUTE[J].Polymer: The International Journal for the Science and Technology of Polymers,1996(18):4215-4220. |
| [11] | Shimada K;Matsushima K;Fukumoto J et al.Poly-(L)-malic acid:a new protease inhibitor from Penicillium cyclopium[J].Biochemical and Biophysical Research Communications,1969,35:619. |
| [12] | Angerer B;Holler E .Large complexes of β-poly(L-malic acid)with DNA polymerase α histones and other proteins in nuclei of growing plasmodia of physarum polycephalum[J].Biochemistry,1995,34:1474. |
| [13] | Doerhoefer S;Windisch C;Angerer B;Lavrik OI;Lee BS;Holler E .The DNA-polymerase inhibiting activity of POIY(beta-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum[J].European Journal of Biochemistry,2002(4):1253-1258. |
| [14] | Rathberger K;Reisner H;Willibald B;Molitoris HP;Holler E .Comparative synthesis and hydrolytic degradation of poly (L-malate) by myxomycetes and fungi.[J].Mycological Research,1999(5):513-520. |
| [15] | Bear M.-M. .Polystereoisomers of 2-butyl and 3,3-dimethyl-2-butyl malic acid esters:configurational structures/properties relationship[J].Polymer: The International Journal for the Science and Technology of Polymers,2000(10):3705-3712. |
| [16] | Ramiandrasoa P;guerin P;Girault J P et al.Poly(malic cid alkyl esters)derived from 4-alkyloxycarbonyl-2-oxetanones obtained via the ketene route[J].POLYMER BULLETIN,1993,30(05):501. |
| [17] | Vert M .Biomedical polymers from chiral lactides and functional lactones:properties and applications[J].Macromolecular Symposia,1986,6:83. |
| [18] | Caron A;Braud C;Bunel C .Blocky structure of copolymers obtained by palladium/carbon-catalyzed hydrogenolysis of benzyl protecting groups as shown by sequence-selective hydrolytic degradation in poly(malic acid)derivatives[J].Polymer,1990,31(09):1797. |
| [19] | He Bin;Wan Yuqing;Bei Jianzhong .Synthesis and cell affinity of functionalized poly(L-lactide-co-β-malic acid)with high molecular weight[J].BIOMATERIALS,2004,25:5239. |
| [20] | Olivier C;Philippe D;Sandrine C-M .New amphiphilic poly [(R,S)-β-malic acid-b-ε-caprolactone] dioblock copolymers by combining anionic and coordination-insertion ring-opening polymerization[J].Macromolecules,2002,35:9896. |
| [21] | Cammas-Marion S.;Guerin P. .Design of malolactonic acid esters with a large spectrum of specified pendant groups in the engineering of biofunctional and hydrolyzable polyesters[J].Macromolecular symposia,2000(0):167-186. |
| [22] | Braud C;Vert M .Degradation of poly(malic acid)monitoring of oligomers formation by aqueous size-exclusion chromatography(SEC)and high-performance capillary electrophoresis(HPCE)[J].POLYMER BULLETIN,1992,29(1-2):177. |
| [23] | Braud C;Vert M .Poly(β-malic acid)based biodegradable polyesters aimed at pharmacological uses[J].Trends in Polymer Science,1993,3:57. |
| [24] | Holler E.Handbook of engineering polymeric materials[M].New York:Marcel Dekker,Inc,1997:93. |
| [25] | Mauduit J;Boustta M;Vert M .Hydrolytic degradation of benzylated poly(malic acid):influence of sample size,sample shape,and polymer composition[J].Journal of Biomaterials Science-Polymer Edition,1995,7(03):207. |
| [26] | Stolnik S;Garnett M C;Davies M C et al.Nanospheres prepared from poly(malic acid)benzyl ester copolymers:evidence for their in vitro degradation[J].Journal of Materials Science:Materials in Medicine,1996,7(03):161. |
| [27] | Krell M;Seebach D .Preparation of free and of specifically protected oligo [Malic Acids] for enzymatic degradation studies[J].European Journal of Organic Chemistry,2000,7:1207. |
| [28] | Domurado D;Fournie P;Braud C et al.In vivo fates of degradable poly(malic acid)and of its precursor,malic acid[J].Journal of Bioactive and Compatible Polymers,2003,18(01):23. |
| [29] | Ouchi T;Kobayashi H;Banba T .Design of poly(rnalic acid)-5FU conjugate exhibiting antitumor activity[J].POLYMER JOURNAL,1990,23(03):221. |
| [30] | Ohya Y;Hirai K;Ouchi T .Synthesis and cytotoxic activity of doxorubicin bound to poly(malic acid)via ester or amide bonds[J].MAKROMOLEKULARE CHEMIE,1992,193(08):1881. |
| [31] | Yoncheva K;Miloshev S;Belcheva N;Lambov N .Development and characterization of cross-linked poly(malate) microspheres with dipyridamole.[J].International Journal of Pharmaceutics,2001(1/2):31-37. |
| [32] | Osanai S;Nakamura K .Effects of complexation between liposome and poly(malic acid) on aggregation and leakage behaviour.[J].Biomaterials,2000(9):867-876. |
| [33] | Cammas-Marion S.;Harada A.;Guerin P.;Kataoka K.;Bear MM. .New macromolecular micelles based on degradable amphiphilic block copolymers of malic acid and malic acid ester[J].Macromolecular chemistry and physics,2000(3):355-364. |
| [34] | Jeanbat M V;Barbaud C;Caruelle J P .Bioactive functionalized polymer of malic acid for bone repare and muscle regeneration[J].Journal of Biomaterials Science-Polymer Edition,2000,9:979. |
| [35] | Cammas S;Bear M M;Moine L .Polymers of malic acid and 3-alkylmalic acid as synthetic PHAs in the design of biocompatible hydrolyzable devices[J].International Journal of Biological Macromolecules,1999,25:273. |
| [36] | 余文兵,周华,韦萍.生物降解材料聚苹果酸的合成方法及应用进展[J].化工进展,2004(10):1086-1090. |
| [37] | Stolnik S;Garnett M C;Davies M C et al.The colloidal properties of surfactant-free biodegradable nanospheres from poly(malic acid-co-benzyl malate)s and poly(lactic acid-coglycolide)[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,1995,97(03):235. |
| [38] | C.Regano;A.Alla;A.Martinez de Ilarduya;S.Munoz-Guerra .Poly(ester amide)s Derived from L-Malic Acid[J].Macromolecules,2004(6):2067-2075. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%