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采用改性Hummers法制备了氧化石墨烯,并探索了其在生物医学方面作为纳米药物载体的应用.通过超声、振荡等方法制备了氧化石墨烯盐酸阿霉素(GO-DXR),采用高分辨透射电镜(HRTEM)、傅里叶变换红外光谱(FT-IR)、紫外-可见分光光谱(UVVis)等测试方法对GO负载DXR前后的形貌和结构进行了研究.DXR在GO上的负载量高达4.6mg/mg,DXR的释放量可通过pH值控制,说明GO与DXR之间依靠氢键作用结合.

参考文献

[1] 马垠智,曹宏明,黄广建,吴秋芳,张海英,於定华.铁炭复合磁靶向缓释药物载体材料的制备--制备条件对铁炭复合材料磁性能的影响[J].功能材料,2004(04):423-425.
[2] 逯敏飞,程永清,李丽君,伍建军.被动靶向药物载体的研究进展[J].材料导报,2005(09):108-110.
[3] 金丽霞.纳米药物载体的研究及临床应用[J].中国组织工程研究与临床康复,2010(08):1429-1432.
[4] Xiaoying Yang;Xiaoyan Zhang;Zunfeng Liu .High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2008(45):17554-17558.
[5] Novoselov K S;Geim A K;Morozov S V et al.Electric field effect in atomically thin carbon films[J].Science,2004,306:666-669.
[6] Novoselov K S;Geim A K;Morozov S V et al.Two-dimensional gas of massless dirac fermions in grapheme[J].Nature,2005,438:197-200.
[7] Hernandez Y;Nicolosi V;Lotya M;Blighe FM;Sun ZY;De S;McGovern IT;Holland B;Byrne M;Gun'ko YK .High-yield production of graphene by liquid-phase exfoliation of graphite[J].Nature nanotechnology,2008(9):563-568.
[8] Banhart F;Ajayan P M .Carbon onions as nanoscopic pressure cells for diamond formation[J].Nature,1996,382:433-435.
[9] Chae HK;Siberio-Perez DY;Kim J;Go Y;Eddaoudi M;Matzger AJ .A route to high surface area, porosity and inclusion of large molecules in crystals[J].Nature,2004(6974):523-527.
[10] Xiaoying Yang;Yinsong Wang;Xin Huang .Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2011(10):3448-3454.
[11] Sun Xiaoming;Liu Zhuang et al.Nano graphene oxide for cellular imaging and drug delivery[J].Nano Res,2008,1:203-212.
[12] Zhang, LM;Xia, JG;Zhao, QH;Liu, LW;Zhang, ZJ .Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs[J].Small,2010(4):537-544.
[13] 沈贺,张立明,张智军.石墨烯在生物医学领域的应用[J].东南大学学报(医学版),2011(01):218-223.
[14] Zheng,X.T.;Li,C.M. .Restoring basal planes of graphene oxides for highly efficient loading and delivery of β-lapachone[J].Molecular pharmaceutics,2012(3):615-621.
[15] Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting[J].Journal of Materials Science. Materials in Medicine,2009(1):301.
[16] Depan, D.;Shah, J.;Misra, R.D.K. .Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2011(7):1305-1312.
[17] Ma Xinxing;Tao Huiquan et al.A functionalized graphene oxide iron oxide nanocomposite for magnetically targeted drug delivery,photothermal therapy,and magnetic resonance imaging[J].Nano Res,2012,5(03):199-212.
[18] Zhang W;Guo Z;Huang D;Liu Z;Guo X;Zhong H .Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide.[J].Biomaterials,2011(33):8555-8561.
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