由于材料表面类骨磷灰石的形成是材料是否具有生物活性的关键因素.因此,本文研究了等离子体活化改性的双相钙磷陶瓷(HA/TCP)在模拟体液(SBF)中形成类骨磷灰石的表面形貌、组成和结构,并探讨活化和沉积的机理.结果发现等离子体处理的HA/TCP更容易形成类骨磷灰石.其机理是等离子体中的高能、高活性的粒子轰击HA/TCP,使其表面刻蚀和粗化,也使HA/TCP晶体产生畸变活化,从而增加了钙磷陶瓷的溶解性,易使局部钙、磷离子浓度达到过饱和,有利于类骨磷灰石的成核和生长.表明等离子体表面改性提高了材料的活性.有利于促进骨的形成和生长.
参考文献
| [1] | 苏葆辉,冉均国,陈治清.低温等离子体处理聚羟基磷酸钙钠提高生物活性的研究[J].航天医学与医学工程,2003(01):68-71. |
| [2] | El-ghannam A E;Ducheyne P;Shapiro I .[J].Journal of Orthopaedic Research,1999,17:340-345. |
| [3] | Garcia AJ;Ducheyne P;Boettiger D .Effect of surface reaction stage on fibronectin-mediated adhesion of osteoblast-like cells to bioactive glass.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(1):48-56. |
| [4] | el Ghannam A;Ducheyne P;Shapiro IM .Bioactive material template for in vitro synthesis of bone.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1995(3):359-370. |
| [5] | Zhang X D.Initiation of the Osteoinduction in Calciumphosphate Ceramics without the Bone Growth Factor[C].USA:Trans of 19th Annual Meeting of the Society for Biomaterials,Birmingham,AL,1993:299. |
| [6] | Hench L L;Wilson J .[J].Science,1984,226:630. |
| [7] | Kokubo T .[J].Biomaterials,1991,12:155-63. |
| [8] | Hench L L.The Challenge of Orthopaedic Materials[M].Current Orthopaedics,2000 |
| [9] | Kokubo T;Ito S;Yamamuro T et al.[J].Journal of Biomedical Materials Research,1990,24:331-343. |
| [10] | 苏葆辉;冉均国 等.[J].稀有金属材料与工程,2002,31(01):491. |
| [11] | Nakamura T;Neo M;Kokubo T.Bone Boding of Biomaterials and Apatite Formation on Biomaterials in Mineralization in natural and synthetic biomaterials[M].USA:Publish by MRS,Warrendale,PA,2000:15-26. |
| [12] | 苏葆辉;冉均国 等.[J].生物医学工程学杂志,2002,19(02):33-34. |
| [13] | 孟广耀.化学气相淀积与无机新材料[M].北京:科学出版社,1984:120-123. |
| [14] | Weng Jie;Zhang Xingdong;de Groot K .[J].BIOMATERIALS,1997,18:1027-1035. |
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