以广藿香油为芯材,壳聚糖和阿拉伯胶为壁材.采用复凝聚法对广藿香油进行包埋,制备广藿香油微胶囊.利用扫描电子显微镜、激光粒度仪、红外光谱和紫外光谱等分析方法研究各因素对微胶囊形成的影响.确定制备广藿香油微胶囊的最佳条件:采用中低粘度的壳聚糖,壳聚糖浓度为0.5％,阿拉伯胶浓度为4％,芯壁比为1∶2,复凝聚pH值为4.5,搅拌转速为2000 r/min.红外光谱分析表明广藿香油包埋成功,其载药量和包封率分别为20.75％和67.2％.微胶囊缓释性能测试结果表明微胶囊具有良好的缓释效果,在25℃条件下,微胶囊释放150 h后,累计释放率为33％,即微胶囊保留率为67％.
参考文献
| [1] | 刘亮锋,黄晓丹,蔡大可,刘玮锦,苏冀彦,赖平,苏子仁.广藿香油及藿香油的研究概况[J].中国中医药信息杂志,2009(02):100-102. |
| [2] | 栾淑华.广藿香挥发油提取工艺研究[J].辽宁中医药大学学报,2006(04):127. |
| [3] | 王国光,施萍萍,江颖.广藿香挥发油成分及其药理研究[J].内蒙古中医药,2011(04):49-50. |
| [4] | 张仲敏,黎玉翠,彭绍忠,暴梅佳,易宇阳,赖小平,苏子仁.广藿香醇研究概述[J].中国中医药信息杂志,2012(01):110-112. |
| [5] | 程雪宁 .广藿香质量标准和制备工艺研究[D].北京化工大学,2010. |
| [6] | 李建春,傅莺,孙玉明.广藿香挥发油β-环糊精包合工艺的研究[J].湖北中医杂志,2001(04):52. |
| [7] | 常明,岳红坤,牟微,李慧,郭敬敬.蓖麻油缓释微囊的研制[J].安徽农业科学,2011(10):6085-6087. |
| [8] | 黄亮亮 .壳聚糖复合微胶囊的制备及性质研究[D].济南大学,2008. |
| [9] | 王双华,张恒,段成金,张军.微胶囊制备技术及其应用[J].材料导报,2006(z2):376-379. |
| [10] | 周建林,罗艳,钟毅.复凝聚法制备磁性微胶囊及其磁响应特性[J].材料导报,2012(10):54-57. |
| [11] | Wei, Z.;Wang, C.;Zou, S.;Liu, H.;Tong, Z. .Chitosan nanoparticles as particular emulsifier for preparation of novel pH-responsive Pickering emulsions and PLGA microcapsules[J].Polymer: The International Journal for the Science and Technology of Polymers,2012(6):1229-1235. |
| [12] | Shi XY;Tan TW .Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D2.[J].Biomaterials,2002(23):4469-4473. |
| [13] | 张可达,徐冬梅,王平.微胶囊化方法[J].功能高分子学报,2001(04):474-480. |
| [14] | Agnihotri SA;Mallikarjuna NN;Aminabhavi TM .Recent advances on chitosan-based micro- and nanoparticles in drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(1):5-28. |
| [15] | Liangliang Huang;Weiping Sui;Yuanxiu Wang .Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2010(1):168-173. |
| [16] | Sudipta Chatterjee;Fabien Salaun;Christine Campagne .Preparation of microcapsules with multi-layers structure stabilized by chitosan and sodium dodecyl sulfate[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2012(2):967-975. |
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