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制备了庆大霉素、磷酸钙骨水泥药物缓释体系,研究了药物缓释效果及载入庆大霉素对骨水泥组成、结构与性能的影响.结果表明,庆大霉素、磷酸钙骨水泥体系具有良好的药物缓释效果;随着庆大霉素的载入,骨水泥的凝结时间延长,但当载入量达到5%时,骨水泥的凝结时间又缩短至15 min,继续增大药物含量,凝结时间又略有延长.低载药量(1%)时骨水泥的抗压强度有所提高,但再继续增大载药量,体系的抗压强度又逐渐下降.庆大霉素的加入对骨水泥的最终水化产物没有明显影响,水化产物都是弱结晶的羟基磷灰石.庆大霉素的载入量为3%~5%时,庆大霉素/磷酸钙骨水泥缓释体系具有最佳的综合性能.

参考文献

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