采用静电层层自组装技术构建了以I型胶原蛋白（COL）为主要构成的纳米超薄膜。该类型薄膜厚度与涂层层数呈线性关系。通过“喷涂”方式，在未经任何理化作用处理的生物可降解聚酯材料表面可原位形成厚度可控的胶原蛋白薄膜结构，改善聚酯材料的亲水性。在小鼠成纤维细胞（L929）培养实验中，聚乳酸（PLA）表面负载多层膜以后，表现出良好的细胞生物相容性，有利于细胞的生长和铺展。
Nanometer thin films with type I collagen as main component were constructed by electrostatic layer- by-layer self assembly technique. The thickness and the plies of the films show linearly elationship. By the way of spraying, the thickness-controllable collagen films could be in-situ formed on the surface of biodegradable polyester materials without any chemical treatment to improve the hydrophilicity of the polyester materials greatly. In the mouse fibroblast (L929) culture experiments, polylatic acid (PLA) covered multilayer films demonstrated good biocompatibility.
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