为了改善壳聚糖材料的血液相容性能,在醋酸体系中制备了壳聚糖(CTS)/聚-(R)-3-羟基丁酸酯(PHB)/聚乙二醇(PEG)的多元共混复合材料,复合膜材料的基本理化性质经FT-IR、广角X粉末衍射(WAXD)、SEM和水溶胀率测定表征,体外评价了CTS/PHB/PEG多元共混膜的血液相容性.结果显示,共混物组分间存在一定的化学作用,共混膜的结晶行为受CTS控制,PHB和PEG的加入对CTS材料的表面形貌及亲水性能有较大影响.三元共混膜较CTS在溶血率、复钙化时间、动态凝血曲线等血液相容性能方面有所改善,膜表面血小板粘附减少,表现出良好的抗凝血性能.
参考文献
| [1] | Zhou Yongguo;Yang Yuedong;Hou Wenlong .[J].Chinese Polymer Bulletin,2008,6:28-34. |
| [2] | Shi Yanchao;Ma Lie;Zhou Jie .[J].Polymers For Advanced Technologies,2006,16(11):789-794. |
| [3] | Honma T;Zhao L;Asakawa N;Inoue Y .Poly(epsilon-caprolactone)/chitin and poly (epsilon-caprolactone)/chitosan blend films with compositional gradients: Fabrication and their biodegradability[J].Macromolecular bioscience,2006(3):241-249. |
| [4] | Cai Zhijiang;Wang Ling;Hou Xin .[J].Journal of Biomedical Engineering,2002,19(02):306-315. |
| [5] | Ikejima T;Inoue Y .Crystallization behavior and environmental biodegradability of the blend films of poly (3-hydroxybutyric acid) with chitin and chitosan[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2000(4):351-356. |
| [6] | Galo C T;Johana S L;Lucia H .[J].Bol Soc Chil Quím,2002,47(04):529-533. |
| [7] | 孟晓荣,杨晓光,张敏.壳聚糖-聚羟基丁酸酯共混膜的制备与性质[J].功能高分子学报,2007(04):364-368. |
| [8] | 孟晓荣,王琼,杨晓光,张宏洲,张敏.壳聚糖/聚羟基丁酸酯接枝共聚物的合成及血液相容性[J].高分子材料科学与工程,2009(07):9-12. |
| [9] | 孟晓荣,江元汝,王琼,杨晓光,张敏.壳聚糖-聚羟基丁酸酯共混膜的体外血液相容性评价[J].功能材料,2009(03):436-438,442. |
| [10] | 汪多仁.聚乙二醇的应用与合成进展[J].化学工业与工程技术,2000(05):21-23. |
| [11] | 何领好,杨德彬,薛瑞,刘莹,宋锐.壳聚糖/聚乙二醇共混膜的制备与表征[J].郑州轻工业学院学报（自然科学版）,2007(01):10-13. |
| [12] | 宋艳秋,原续波,盛京.疏水性聚砜膜的共混改性研究[J].化学工业与工程,2002(01):32-35,49. |
| [13] | 郝文涛,杨文,黄文锐,王丽萍,胡嘉维.壳聚糖与水溶性高分子相容性的研究进展[J].材料导报,2007(12):49-51. |
| [14] | Andrade J D .[J].MEDICAL INSTRUMENTATION,1973,7(02):110-119. |
| [15] | Lens J P;Harmsen P F;Schegget E M .[J].Journal of Biomaterials Science:Polymer Edition,1997,8(12):963-982. |
| [16] | Kulkarni AR;Hukkeri VI;Sung HW;Liang HF .A novel method for the synthesis of the PEG-crosslinked chitosan with a pH-independent swelling behavior[J].Macromolecular bioscience,2005(10):925-928. |
| [17] | Chin-San Wu .A comparison of the structure,thermal properties,and biodegradability of polycaprolactone/chitosan and acrylic acid grafted polycaprolactone/chitosan[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(1):147-155. |
| [18] | 陈柄灿,霍丹群,饶佳家,任彦荣.新型抗凝血生物材料的合成及其血液相容性的研究[J].功能材料,2004(05):649-650,653. |
| [19] | 彭承宏,赵之明,刘宏,韩宝三,王涌,方河清,吴育连,高长有.一种新型生物人工肝膜材料体外激活血小板的实验[J].中国病理生理杂志,2005(02):289-292. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%