采用以聚电解/盐复合体为模板的纳米粒子自组装微囊法,利用分子间的静电作用力,在不添加表面活性剂的条件下,首次将带负电的富勒醇纳米颗粒制备成具有核壳结构的聚丙烯铵盐酸盐/HPO42-/富勒醇复合微胶囊.采用扫描电子显微镜、动态光散射仪、Zeta电位仪等时其进行了表征,并采用邻苯三酚自氧化法测定了微囊时自由基的清除作用.结果发现,该复合微囊接近球形,分散良好且大小均一,微囊直径约为1～2μm,表面电势接近0mV;其对超氧阴离子自由基具有较强清除能力且呈现浓度依赖性.
参考文献
| [1] | Bosi S;Da Ros T;Spalluto G;Prato M .Fullerene derivatives: an attractive tool for biological applications.[J].European Journal of Medicinal Chemistry: Chimie Therapeutique,2003(11/12):913-923. |
| [2] | Pantarotto D;Tagmatarchis N;Bianco A;Prato M .Synthesis and biological properties of fullerene-containing amino acids and peptides.[J].Mini reviews in medicinal chemistry,2004(7):805-814. |
| [3] | Vileno B;Sienkiewicz A;Lekka M et al.In vitro assay of singlet oxygen generation in the presence of water-soluble derivatives of C60[J].CARBO,2004,42(5-6):1195. |
| [4] | Ryan JJ;Bateman HR;Stover A;Gomez G;Norton SK;Zhao W;Schwartz LB;Lenk R;Kepley CL .Fullerene nanomaterials inhibit the allergic response.[J].The Journal of Immunology: Official Journal of the American Association of Immunologists,2007(1):665-672. |
| [5] | Lars O.Husebo;Balaji Sitharaman;Ko Furukawa;Tatsuhisa Kato;Lon J.Wilson .Fullerenols Revisited as Stable Radical Anions[J].Journal of the American Chemical Society,2004(38):12055-12064. |
| [6] | Brant JA;Labille J;Robichaud CO;Wiesner M .Fullerol cluster formation in aqueous solutions: Implications for environmental release[J].Journal of Colloid and Interface Science,2007(1):281-288. |
| [7] | Murthy V S;Rana R K;Wong M S .Nanoparticle-assernbled capsule synthesis:Formation of colloidal polyamine-salt intermediates[J].Journal of Physical Chemistry B,2006,110(51):25619. |
| [8] | Rohit K. Rana;Vinit S. Murthy;Jie Yu;Michael S. Wong .Nanoparticle Self-Assembly of Hierarchically Ordered Microcapsule Structures[J].Advanced Materials,2005(9):1145-1150. |
| [9] | Murthy V S;Wong M S.Nanoscale science and technology in biomolecular catalysis[M].Washington,DC:American Chemical Society,2008:214. |
| [10] | Jing L;Atsuo T;Masaki O.C60 fullerol formation catalysed by quaternary ammonium hydroxides[J].Journal of the Chemical Society,Chemical Communications,1993(23):1784. |
| [11] | 孙涛,金亚旭,陈万喜,张欣欣,陈卫祥,徐铸德.水溶性C60-β丙氨酸衍生物清除超氧阴离子自由基O-·2及对小鼠胸腺细胞生长影响的研究[J].高等学校化学学报,2002(08):1598-1600. |
| [12] | Guzman KAD;Taylor MR;Banfield JF .Environmental risks of nanotechnology: National nanotechnology initiative funding, 2000-2004[J].Environmental Science & Technology: ES&T,2006(5):1401-1407. |
| [13] | Friedman S H;Decamp D L;Sijbesma R P et al.Inhibition of the HIV-1 protease by fullerene derivatives:Model building studies and experimental verification[J].Journal of the American Chemical Society,1993,115(15):6506. |
| [14] | Chiang L Y;Lu F J;Huang H C.Free-radical scavenging activity of water-soluble fullerenols[J].Journal of the Chemical Society,Chemical Communications,1995(12):1283. |
| [15] | Mirkov S M;Djordjevic A N;Andric N L et al.Nitric oxide-scavenging activity of polyhydroxylated fullerenol,C60(OH)24[J].Nitric Oxide:Biology and Chemistry,2004,11(02):201. |
| [16] | Cai X;Jia H;Liu Z;Hou B;Luo C;Feng Z;Li W;Liu J .Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease.[J].Journal of Neuroscience Research,2008(16):3622-3634. |
| [17] | Fang Lao;Wei Li;Dong Han;Ying Qu;Ying Yuliang Zhao;Chunying Chen .Fullerene derivatives protect endothelial cells against NO-induced damage[J].Nanotechnology,2009(22):225103-9. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%