{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"应用芴甲氧羰基(Fmoc)固相方法化学合成了敬钊毒素-V(JZTX-V)分子N-端酪氨酸残基剪切体(Y1-JZTX-V),并且通过反相高效液相色谱和质谱对不同条件下的氧化复性结果进行监测,从而得到该剪切体的最佳氧化复性条件:0.1 mol/L Tris-HCl缓冲液、pH 7.50、1 mmol/L还原型谷胱甘肽(GSH)、0.1 mmol/L氧化型谷胱甘肽(GSSG)、样品浓度为0.05 mg/L、复性温度为4 ℃.膜片钳电生理实验结果显示敬钊毒素-V剪切体Y1-JZTX-V对大鼠背根神经节(DRG)细胞上表达的河豚毒素不敏感型(TTX-R)与河豚毒素敏感型(TTX-S)钠电流均有抑制作用,其半数抑制浓度(IC50)分别为(160±2.5)nmol/L和(39.6±3.2)nmol/L.与天然的敬钊毒素-V相比,该剪切体对大鼠DRG细胞上的TTX-S钠电流的抑制作用基本一致,但对TTX-R钠电流的抑制作用却大大降低,表明敬钊毒素-V分子N-端的酪氨酸残基是一个与TTX-R钠通道结合活性相关的氨基酸残基.","authors":[{"authorName":"全妙华","id":"010c6118-324d-49c8-bd2b-43494f7b1d91","originalAuthorName":"全妙华"},{"authorName":"曾雄智","id":"84148e13-babb-42e8-93cb-695c0f87954a","originalAuthorName":"曾雄智"},{"authorName":"皮建辉","id":"40b4cde9-1c10-4733-b986-7acc689329a0","originalAuthorName":"皮建辉"},{"authorName":"邓梅春","id":"8ec9e42b-c49b-4e55-913f-788f6c28b069","originalAuthorName":"邓梅春"},{"authorName":"梁宋平","id":"03a914bd-da2f-4a12-ad67-926199ad190f","originalAuthorName":"梁宋平"}],"doi":"10.3321/j.issn:1000-8713.2007.04.011","fpage":"501","id":"d890747c-b13b-4e1a-b37c-e9ab6b0339e7","issue":"4","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"9285859d-c277-4682-bc0c-6cd4b2bd75b6","keyword":"化学合成","originalKeyword":"化学合成"},{"id":"7dce1649-0e21-430f-817a-c77ed34e8010","keyword":"敬钊毒素-V剪切体","originalKeyword":"敬钊毒素-V剪切体"},{"id":"eb60fa2b-caae-4c00-b5a9-fa5b283d6bad","keyword":"复性","originalKeyword":"复性"},{"id":"9ae73dc8-d148-4f5c-8e9a-931847dd8d53","keyword":"钠离子通道","originalKeyword":"钠离子通道"}],"language":"zh","publisherId":"sp200704011","title":"敬钊毒素-V剪切体Y1-JZTX-V的化学合成与氧化复性及其钠通道活性鉴定","volume":"25","year":"2007"},{"abstractinfo":"应用芴甲氧羰基(Fmoc)固相化学合成了海南捕鸟蛛毒素-Ⅲ,并优化了其最佳氧化复性条件.最佳的氧化复性条件为pH 7.5的重蒸水溶液体系,样品质量浓度为0.1 g/L,还原型谷胱甘肽和氧化型谷胱甘肽的浓度分别为1.0 mmol/L和0.1 mmol/L、L-Arg浓度为1.0 mol/L.复性产物经质谱测定其相对分子质量为3 607.68;与天然毒素等量混合后用高效液相色谱分析得到单一峰;膈神经-膈肌标本生理实验结果表明,合成的毒素具有与天然毒素相同的生物学活性,从而可确定二者在结构与功能上具有一致性.","authors":[{"authorName":"皮建辉","id":"14513d62-aa5b-4cba-b404-46438c686516","originalAuthorName":"皮建辉"},{"authorName":"全妙华","id":"f3515c74-feed-4647-925c-b8fdaeb8287c","originalAuthorName":"全妙华"},{"authorName":"曾雄智","id":"10dcb661-7ba6-4676-b42e-f290d4a66844","originalAuthorName":"曾雄智"}],"doi":"10.3321/j.issn:1000-8713.2007.03.025","fpage":"399","id":"dadc779f-b2d6-4c7a-8ebe-306f17d22880","issue":"3","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"63967fbc-2aec-451c-a401-d1c1311552f2","keyword":"固相化学合成","originalKeyword":"固相化学合成"},{"id":"5ef3dd35-4fca-445c-8b53-1eeaad57bcfa","keyword":"海南捕鸟蛛毒素-Ⅲ","originalKeyword":"海南捕鸟蛛毒素-Ⅲ"},{"id":"103fa664-5c9c-40b8-a452-735e45164ffe","keyword":"氧化复性","originalKeyword":"氧化复性"},{"id":"49bba8cc-61db-4e41-b123-f11f40627a95","keyword":"结构与功能","originalKeyword":"结构与功能"},{"id":"2bb2c526-10b9-436a-9f65-27372822e052","keyword":"反相高效液相色谱","originalKeyword":"反相高效液相色谱"},{"id":"3d31df74-f9c6-4a42-b18e-d08d46026409","keyword":"基质辅助激光解吸电离飞行时间质谱","originalKeyword":"基质辅助激光解吸电离飞行时间质谱"}],"language":"zh","publisherId":"sp200703025","title":"海南捕鸟蛛毒素-Ⅲ的固相化学合成和氧化复性","volume":"25","year":"2007"},{"abstractinfo":"比较了5种不同商品化脂肪酶和自制的华根霉CCTCC M201021全细胞脂肪酶(RCL)催化油脂合成生物柴油的转化效果,结果表明, RCL能有效应用于无溶剂体系催化合成生物柴油. 在无溶剂体系中对该酶催化生物柴油的转酯化反应工艺进行优化,考察了甲醇用量、体系含水量、酶的添加量和反应温度对生物柴油收率的影响,使生物柴油最终收率大于86.0%. 在有机溶剂体系中选择不同有机溶剂作为助溶剂进行转酯化反应,发现log P值在4.0~4.5的有机溶剂具有较好的转化效果. 其中以正庚烷为助溶剂的转酯化反应具有最高的生物柴油收率86.7%. 在无溶剂体系中RCL催化转化油酸和模拟高酸价油脂合成脂肪酸甲酯的研究表明,该酶具有很好的催化合成生物柴油的潜力.","authors":[{"authorName":"贺芹","id":"aa1dc494-2ae6-4cee-a60c-73b3e7f8bf39","originalAuthorName":"贺芹"},{"authorName":"徐岩","id":"124f3a2f-5486-4cfa-bd8e-440f015d230d","originalAuthorName":"徐岩"},{"authorName":"滕云","id":"46927df5-d869-41fc-a4b3-58afa0bef982","originalAuthorName":"滕云"},{"authorName":"王栋","id":"169b8702-4102-4811-a00f-67ae26ff8a0e","originalAuthorName":"王栋"}],"doi":"","fpage":"41","id":"15f616ac-4c57-47b0-bdbe-0c43f373bb92","issue":"1","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"8ecabbd5-5148-4309-897c-f2728132cb61","keyword":"华根霉","originalKeyword":"华根霉"},{"id":"ce7fb2d1-c66a-407f-b5ce-24ad10187fba","keyword":"全细胞脂肪酶","originalKeyword":"全细胞脂肪酶"},{"id":"8a3e40d7-70e4-465c-98ac-6583cb6365da","keyword":"转酯化反应","originalKeyword":"转酯化反应"},{"id":"2ef6b8d6-7ca8-432e-98f4-a468e459cc32","keyword":"生物柴油","originalKeyword":"生物柴油"},{"id":"6f0665f4-e6be-44a8-9252-f6769f5a385d","keyword":"脂肪酸甲酯","originalKeyword":"脂肪酸甲酯"},{"id":"65a996a2-eccf-48d6-ada1-aa707ba646de","keyword":"无溶剂体系","originalKeyword":"无溶剂体系"},{"id":"a729b645-540c-4cd8-a332-8aaf2f5f37e5","keyword":"高酸价油脂","originalKeyword":"高酸价油脂"}],"language":"zh","publisherId":"cuihuaxb200801010","title":"华根霉全细胞脂肪酶催化合成生物柴油","volume":"29","year":"2008"},{"abstractinfo":"比较了10种不同来源的脂肪酶催化油酸与油醇酯化合成油酸油醇酯的能力,其中华根霉Rhizopus chinensis CCTCC M201021全细胞脂肪酶的催化能力最强,其反应转化率可达到90%以上.酯化反应的最佳油酸/油醇底物摩尔比为1.5, 最佳油酸浓度为0.3 mol/L, 细胞干粉含水量为3.0%~7.5%时对酯化反应最为有利.以生物相容性指数logP值为指标选择不同的有机溶剂作为有机相进行酯化反应,发现logP值为3.5~4.5的有机溶剂促进酯化效果较好.全细胞脂肪酶的pH适应范围很广,最佳pH在9.0左右;最佳反应温度为30 ℃.","authors":[{"authorName":"金亮","id":"ce9c481d-3190-49eb-b927-421f9803c0b0","originalAuthorName":"金亮"},{"authorName":"徐岩","id":"a048584c-9ccf-4c26-827d-57c84b9ce9bd","originalAuthorName":"徐岩"},{"authorName":"曹光群","id":"b8277cec-4060-464c-b33d-03eaa2418aae","originalAuthorName":"曹光群"}],"doi":"","fpage":"611","id":"ffe664f3-b23e-4bd9-9ee0-d34a2b349807","issue":"7","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"97ad7e72-ae94-4333-9db6-a4981e622f13","keyword":"华根霉","originalKeyword":"华根霉"},{"id":"e7c38b1d-27bb-4ada-ac2a-23436c177429","keyword":"脂肪酶","originalKeyword":"脂肪酶"},{"id":"16ffdfbb-f39e-4e08-acdb-42379bd11509","keyword":"生物催化","originalKeyword":"生物催化"},{"id":"02b9ca07-d5dd-40c8-b1cc-23d2433c793c","keyword":"油酸","originalKeyword":"油酸"},{"id":"0a3a71cb-31c4-4e35-bdf3-cc26833c12d4","keyword":"油醇","originalKeyword":"油醇"},{"id":"e7dee477-254b-4e9b-aa37-72a7b1740c46","keyword":"酯化","originalKeyword":"酯化"},{"id":"ab03f814-c655-435f-ac29-0d87d6278b2e","keyword":"油酸油醇酯","originalKeyword":"油酸油醇酯"}],"language":"zh","publisherId":"cuihuaxb200607017","title":"华根霉全细胞脂肪酶催化合成油酸油醇酯","volume":"27","year":"2006"},{"abstractinfo":"分别采用1∶4和1∶6两种不同的灰砂比(水泥/尾砂)制成胶结充填体试块在不同来源地下水水样中浸泡,浸泡后水样中的重金属含量与《地下水质量标准》(GB/T 14848-93)Ⅲ类标准规定的含量限值进行对照分析,考察金属矿山尾砂胶结充填对地下水的污染.结果表明,灰砂比为1∶4和1∶6的金属矿山全尾砂胶结充填体试块放置14 d后分别被6种水样浸泡90 d后均不会使地下水中重金属含量增加,且含量均低于《地下水质量标准》(GB/T 14848-93)Ⅲ类标准规定的含量限值,不会对生产、生活用水产生不良影响,故用于井下空区充填是完全可行的.","authors":[{"authorName":"熊昌狮","id":"622cc7b4-0489-409b-9d44-c6c3e5c44aca","originalAuthorName":"熊昌狮"},{"authorName":"陈云嫩","id":"2433d432-d30e-4502-9dda-a689c64b1c02","originalAuthorName":"陈云嫩"},{"authorName":"吴乐文","id":"f1f4d761-f6b8-40d3-afa3-848a011f01f5","originalAuthorName":"吴乐文"},{"authorName":"张绍国","id":"e4f0d148-06c6-43aa-8ccb-935e08a472d3","originalAuthorName":"张绍国"},{"authorName":"张大超","id":"4e60b886-550d-4986-acf3-ae8a7f161bb1","originalAuthorName":"张大超"},{"authorName":"罗先伟","id":"41cfc413-bd51-40f6-8c71-6add872849bd","originalAuthorName":"罗先伟"},{"authorName":"聂锦霞","id":"e3e8f5ef-878b-4041-9be2-085ca9c78d90","originalAuthorName":"聂锦霞"},{"authorName":"吴速英","id":"3c980b90-e34a-4142-ae02-987f1d8809bc","originalAuthorName":"吴速英"}],"doi":"10.3969/j.issn.2095-1744.2016.01.020","fpage":"85","id":"90500fbd-0412-471b-addc-665120099d27","issue":"1","journal":{"abbrevTitle":"YSJSGC","coverImgSrc":"journal/img/cover/YSJSGC.jpg","id":"76","issnPpub":"2095-1744","publisherId":"YSJSGC","title":"有色金属工程"},"keywords":[{"id":"c91f4367-dad1-42e4-9afa-842616d03c49","keyword":"胶结充填","originalKeyword":"胶结充填"},{"id":"fd166b16-2b0d-4417-b769-ef5f61c51b6e","keyword":"地下水","originalKeyword":"地下水"},{"id":"0de25a81-b884-4bc8-92a0-67c80b00f465","keyword":"重金属","originalKeyword":"重金属"},{"id":"2b130f93-9c50-41cf-a9c0-40a4238bd903","keyword":"金属矿山","originalKeyword":"金属矿山"}],"language":"zh","publisherId":"ysjs201601020","title":"华锡铜坑矿全尾砂胶结充填对地下水中重金属含量的影响","volume":"6","year":"2016"},{"abstractinfo":"根据《吴仲华奖励基金章程》(吴奖[2008]01号),经各高等院校、中国工程热物理学会和中国科学院工程热物理研究所认真评选和推荐,吴仲华奖励基金理事会评审并确定授予青年学者戴巍、罗坤、唐桂华“吴仲华优秀青年学者奖”,授予程雪涛等10位同学“吴仲华优秀学生奖”。","authors":[],"doi":"","fpage":"0003","id":"6f0ba2a8-05d9-4d8a-8139-230c2fa7e582","issue":"2","journal":{"abbrevTitle":"GCRWLXB","coverImgSrc":"journal/img/cover/GCRWLXB.jpg","id":"32","issnPpub":"0253-231X","publisherId":"GCRWLXB","title":"工程热物理学报 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