采用静电纺丝法,以丝素(SF)、胶原(COL)混合聚左旋乳酸(PLLA)和聚(左旋乳酸-己内酯)(PLCL),制备不同质量配比的SF/COL/PLLA和SF/COL/PLCL三维纳米纤维支架材料,采用傅里叶红外光谱(FTIR)分析高分子聚合物对丝素、胶原结构的影响,测量接触角以检测其亲水性能.结果表明:高分子聚合物破坏丝素胶原之间形成的氢键,使以β折叠结构为主的SF变为以无规卷曲和α螺旋结构为主;当SF/COL与高聚物质量比为70∶30时,接触角θ＜90°,液体对三维纳米纤维支架材料的润湿性较好,且SF/COL/PLCL的亲水性比SF/COL/PLLA的亲水性更优.
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