以端氨基聚乙二醇单甲醚(MPEG-NH2)为引发剂,聚合N-羧基-丙氨酸-环内酸酐(NCA)得到聚L-丙氨酸-聚乙二醇单甲醚嵌段共聚物(PLAM),并接枝叶酸,制得叶酸偶联的叶酸-聚L-丙氨酸-聚乙二醇单甲醚嵌段共聚物(FOL-PLAM).利用FT-IR、1HNMR等分析方法确认了聚合物PLAM和FOLPLAM的结构及分子量.FOL-PLAM有望成为一种抗肿瘤药物靶向输送的新型载体.
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