应用正交设计法选取阿仑膦酸钠（ALN）加入超高分子量聚乙烯（UHMWPE）后均匀分散的最佳工艺参数，运用社会科学统计软件包（SPSS）对正交实验结果进行极差与方差分析，在最佳工艺参数下制备ALN／UHMWPE，通过拉伸力学性能实验、XRD、DSC、SEM及EDS表征样品性能。由正交实验得出ALN加入后均匀分散最佳工艺条件：表面活性剂F68，分散方式为超声分散，ALN质量分数1％，分散温度37℃；方差分析表明，实验具有统计学意义；拉伸力学实验结果表明，表面活性剂F68的加入可以有效提高（ALN—F68）／UHMWPE拉伸强度与断裂伸长率；加入表面活性剂样品的结晶度较未加表面活性剂对照样有所提高，但均低于空白UHMWPE，ALN没有改变uHMWPE晶型及其热熔性质；加入表面活性剂有助于AI。N在UHMWPE中的均匀分散。
The optimum processing conditions were determined by orthogonal design to prepare ultrahigh molecular weight polyethylene loaded with sodium alendronate （ALN/UHMWPE）. The range analysis and analysis of variance（ANOVA） of tensile strength and broken elongation were carried out by statistiacl package for the social science （SPSS）. The tensile test, XRD , DSC, SEM and EDS were used to characterize ALN/UHMWPE prepared under the optimum processing conditions. The orthogonal design combined with statistical analyses reveals that the optimal processing conditions for the uniform dispersion of ALN in UHMWPE are as follows： surfactant （F68）, ultra sonic dispersion, 1 % mass fraction of ALN and at 37 ℃. ANOVA shows a significant difference. The tensile tests indicate that both tensile strength and broken elongation of （ALN- F68）/UHMWPE increase compared with ALN/UHMWPE. The crystallinity of （ALN -FgB）/UHMWPE is slightly higher than that of ALN/UHMWPE, both of which are lower than UHMWPE. No phase or melting behavior changes resulting from ALN addition are observed. The addition of F68 leads to a more uniform distribution of ALN in （ALN - F68）/UHMWPE.
参考文献
| [1] | Steven M K. The UHMWPE handbook: Ultra-high molecular weight polyethylene in total joint replacement [M]. New York: Academic Press Inc, 2004, 1-10. |
| [2] | Agarwal S. Osteolysis basic science, incidence and diagnosis [J]. Current Orthopaedics, 2004, 18: 220-231. |
| [3] | Ma T, Huang Z N, Ren P G, et al. An in vivo murine model of continuous intramedullary infusion of polyethylene particles [J]. Biomaterials, 2008, 29: 3738-3742. |
| [4] | 李宏斌, 朱振安, 毛远青, 等. 阿仑膦酸钠预防磨损颗粒诱导假体周围骨溶解的作用机制 [J]. 中华实验外科杂志, 2006, 23 (2): 154-156. |
| [5] | 刘晓民. 载阿仑膦酸钠超高分子量聚乙烯的研究 . 成都: 西南交通大学, 2010. |
| [6] | 屈树新, 杨 丹. 载阿仑膦酸钠超高分子量聚乙烯力学性能研究 [J]. 医用生物力学, 2009, 24(5): 338-342. |
| [7] | 任 俊, 卢寿慈. 超细颗粒在液相中的分散 [J]. 中国粉体工业, 2006(5): 13-17. |
| [8] | Safaa A, Tarun G. Wear rate model for UHMWPE in total joint applications [J]. Wear, 2008, 265: 8-13. |
| [9] | Liu A Q, Qu S X, Chao M M, et al. UHMWPE carrying estradiol to treat the particle-induced osteolysis—Processing and characterizing [J]. Journal of Biomedical Material Research A, 2009, 90: 496-505. |
| [10] | 王元瑞, 任 亮, 孟庆新, 等. UHMWPE/PA1010 塑料合金的制备及性能 [J]. 复合材料学报, 2009, 26(5): 54-59. |
| [11] | 刘全勇, 胡庆华, 张立群. 溶剂辅助原位分散纳米二氧化硅/聚酯生物弹性体复合材料的制备、结构及性能 [J]. 复合材料学报, 2011, 28(1): 1-7. |
| [12] | Chen J L, Au K C, Wong Y S, et al. Using orthogonal design to determine optimal conditions for biodegradation of phenanthrene in mangrove sediment slurry [J]. Journal of Hazardous Materials, 2010, 176: 666-671. |
| [13] | 张福生, 郭顺星. SPSS正交设计在福建金线莲组织培养中的应用 [J]. 中国中药杂志, 2009, 34(20): 2581-2584. |
| [14] | 金日光, 华幼卿. 高分子物理 [M]. 北京, 化学工业出版社, 2006: 220-247. |
| [15] | Sauter C, Emin M A, Schuchmann H P, et al. Influence of hydrostatic pressure and sound amplitude on the ultrasound induced dispersion and de-agglomeration of nanoparticles [J]. Ultrasonics Sonochemistry, 2008, 15: 517-523. |
| [16] | Ren J, Wang W M, Lu S C, et al. Characteristics of dispersion behavior of fine particles in different liquid media [J]. Powder Technology, 2003, 13: 91-94. |
| [17] | 何 芳, 王玉林, 万怡灶, 等. 三维编织超高分子量聚乙烯纤维/碳纤维/环氧树脂混杂复合材料力学行为及混杂效应研究 [J]. 复合材料学报, 2008, 25(6): 52-58. |
| [18] | Wang H. Dispersing carbon nanotubes using surfactants [J]. Current Opinion in Colloid & Interface Science, 2009, 14: 364-371.. |
| [19] | Khorasani M T, Zaghiyan M, Mirzadeh H. Ultra high molecular weight polyethylene and polydimethylsiloxane blend as acetabular cup material [J]. Colloids and Surfaces B: Biointerfaces, 2005, 41: 169-174. |
| [20] | Reggiani M, Tinti A, Taddei P, et al. Phase transformation in explanted highly crystalline UHMWPE acetabular cups and debris after in vivo wear [J]. Journal of Molecular Structure, 2006, 785: 98-105. |
| [21] | 龚国芳, 漆宗能, 杨华勇. 两类高岭土填充UHMWPE基复合材料及其摩擦磨损特性 [J]. 复合材料学报, 2002, 19(6): 82-86. |
| [22] | Ge S R, Wang S B, Huang X L. Increasing the wear resistance of UHMWPE acetabular cups by adding natural biocompatible particles [J]. Wear, 2009, 267: 770-776. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%